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Maternal microbiome disturbance induces deficits in the offspring's behaviors: a systematic review and meta-analysis.
Hassib, Lucas; de Oliveira, Cilene Lino; Rouvier, Guilherme Araujo; Kanashiro, Alexandre; Guimarães, Francisco Silveira; Ferreira, Frederico Rogério.
Afiliação
  • Hassib L; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • de Oliveira CL; Department of Mental Health, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Rouvier GA; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Kanashiro A; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Guimarães FS; Federal Institute of Education, Science, And Technology of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ferreira FR; Department of Dermatology, Medical Sciences Center, University of Wisconsin-Madison, Madison, WI, USA.
Gut Microbes ; 15(1): 2226282, 2023.
Article em En | MEDLINE | ID: mdl-37400971
Recent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = -0.51, 95% CI = -0.79 to -0.22, p < .001, T2 = 0.54, I2 = 79.85%), indicating that MMD might provoke behavioral impairments in the adult offspring. The MMD also induces a significant effect size for the reduction of the sociability behavior (SMD = -0.63, 95% CI = -1.18 to -0.07, p = 0.011, T2 = 0.30, I2 = 76.11%) and obsessive-compulsive-like behavior (SMD = -0.68, 95% CI = -0.01 to -1.36, p = 0.009, T2 = 0.25, I2 = 62.82%) parameters. The effect size was not significant or inconclusive for memory and anxiety-like behavior, or inconclusive for schizophrenia-like and depressive-like behavior. Therefore, experimental perinatal MMD is vertically transmitted to the offspring, negatively impacting behavioral parameters related to psychiatric disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiota / Microbioma Gastrointestinal / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Systematic_reviews Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Gut Microbes Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiota / Microbioma Gastrointestinal / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Systematic_reviews Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Gut Microbes Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos