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Nicotine promotes Mycobacterium tuberculosis H37Rv growth and overexpression of virulence genes.
Rivas-Santiago, Bruno; de Haro-Acosta, Jeny; Carlos, Adrian Rodríguez; Garcia-Hernandez, Mariana H; Serrano, Carmen J; Gonzalez-Curiel, Irma; Rivas-Santiago, Cesar.
Afiliação
  • Rivas-Santiago B; Biomedical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
  • de Haro-Acosta J; Biomedical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
  • Carlos AR; Biomedical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
  • Garcia-Hernandez MH; Biomedical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
  • Serrano CJ; Biomedical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
  • Gonzalez-Curiel I; Immunotoxicology and Experimental Therpeutics Laboratory, Academic Unit of Chemical Sciences, University Autonomous of Zacatecas, Zacatecas, México.
  • Rivas-Santiago C; CONACYT-Academic Unit of Chemical Sciences, University Autonomous of Zacatecas, Zacatecas, Mexico.
Microbiol Immunol ; 67(8): 365-376, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37380811
Tobacco consumption increases the susceptibility to develop infectious diseases such as tuberculosis (TB). Nicotine (Nc) is the main component of cigarette smoke with immunomodulatory properties, however, its effect on Mycobacterium tuberculosis (Mtb) has been scarcely investigated. The present study evaluated the effect of nicotine on the growth of Mtb and on the induction of virulence-related genes. Mycobacteria were exposed to different concentrations of nicotine then Mtb growth was evaluated. Subsequently, the expression of the virulence-related genes lysX, pirG, fad26, fbpa, ompa, hbhA, esxA, esxB, hspx, katG, lpqh, and caeA was evaluated by RT-qPCR. The effect of nicotine on intracellular Mtb was also evaluated. The results showed that nicotine promotes the growth of Mtb both extracellularly and intracellularly and increases the expression of genes related to virulence. In summary, nicotine promotes the growth of Mtb and the expression of virulence-related genes that could be correlated with the increased the risk of smokers developing TB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Microbiol Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Microbiol Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Austrália