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Adverse reactions to antimicrobials in pediatric patients admitted to a tertiary hospital: a cohort study.
Leitzke, Luísa Rodrigues Furtado; Lenhart, Gabriele; Rocha, Allan Lemos; Zamberlan, Samantha; Gnatta, Diego; da Costa Lima, Elisangela; Heineck, Isabela.
Afiliação
  • Leitzke LRF; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil luisarfurtado@gmail.com.
  • Lenhart G; Hospital Mãe de Deus, Porto Alegre, Brazil.
  • Rocha AL; Departamento de Estatística, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Zamberlan S; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Gnatta D; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • da Costa Lima E; Departamento de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Heineck I; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Eur J Hosp Pharm ; 2023 Jun 27.
Article em En | MEDLINE | ID: mdl-37369595
BACKGROUND: Antimicrobials are widely used in hospitals and are often associated with adverse drug reactions (ADRs). The objective of this study was to determine the incidence of ADRs caused by antimicrobials and classify them according to the type of reaction, the class of antimicrobials used, causality, severity and avoidability. METHODS: A prospective cohort study was carried out with paediatric patients for 6 months. Causality was verified using the Naranjo and Liverpool algorithms, the severity was verified with the adapted scale of Hartwig and the avoidability was verified with the Liverpool Avoidability Assessment Tool. RESULTS: A total of 303 patients were followed, and 18.2% (55/303) of them had one or more ADRs during the hospital stay. Just over half of the patients (28/55) had diarrhea. The most used antimicrobials were beta-lactams and second-generation cephalosporins. Suspicions were classified mainly as possible 78.6% (55/70) according to the Naranjo algorithm, and as probable 48.6% (34/70) according to the Liverpool algorithm. The antimicrobial most involved with ADRs was cefepime. The risk of manifesting ADR was greater with the use of some antimicrobials such as clindamycin (relative risk (RR) 3.0, CI 1.67 to 5.4), as well as with the increase in hospitalisation days (OR 1.022, CI 1.008 to 1.036) and in the number of antimicrobials prescribed (OR 1.649, CI 1.360 to 2.001). CONCLUSION: ADRs were observed in approximately one-fifth of patients and were mostly gastrointestinal, moderate, unavoidable and with variable causality, depending on the algorithm used.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Eur J Hosp Pharm Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Eur J Hosp Pharm Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido