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The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions.
Rodrigues, Patrícia Brito; Dátilo, Marcella Neves; Sant'Ana, Marcella Ramos; Nogueira, Guilherme Augusto da Silva; Marin, Rodrigo Miguel; Nakandakari, Susana Castelo Branco Ramos; de Moura, Leandro Pereira; da Silva, Adelino Sanchez Ramos; Ropelle, Eduardo Rochete; Pauli, José Rodrigo; Cintra, Dennys Esper.
Afiliação
  • Rodrigues PB; Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • Dátilo MN; Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • Sant'Ana MR; Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • Nogueira GADS; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, UNICAMP, São Paulo, Brazil.
  • Marin RM; Laboratory of Clinical Investigation in Resistance to Insulin - LICRI - Department of Internal Medicine - UNICAMP, São Paulo, Brazil.
  • Nakandakari SCBR; Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • de Moura LP; Laboratory of Molecular Biology of Exercise, LaBMEx, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • da Silva ASR; School of Physical Education and Sport, University of São Paulo, USP, São Paulo, Brazil.
  • Ropelle ER; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Laboratory of Molecular Biology of Exercise, LaBMEx, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • Pauli JR; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Laboratory of Molecular Biology of Exercise, LaBMEx, School of Applied Sciences, UNICAMP, São Paulo, Brazil.
  • Cintra DE; Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil. Electronic address: dcintra@yahoo.com.
J Nutr Biochem ; 119: 109410, 2023 09.
Article em En | MEDLINE | ID: mdl-37364793
The gut has been suggested as the first organ to be affected by unbalanced diets contributing to the obesogenic process. This study aimed to test a short time-course exposition model to a known pro- or anti-inflammatory enriched fatty diet to understand the early gut alterations. Male mice were exposed to the chow diet (CT), high-fat (HF) diet, or a high-fat diet partially replaced on flaxseed oil (FS), rich in omega-3 (ω3), for 14 days. HF and FS increased the total body weight mass compared with the CT group, but FS reduced the epididymal fat depot compared to HF. The bioinformatics from mice and human databases showed the Zo1-Ocln-Cldn7 tight junctions as the main protein-triad. In the ileum, the HF diet has increased IL1ß transcript and IL1ß, TNFα, and CD11b proteins, but reduced the tight junctions (Zo1, Ocln, and Cld7) compared to the CT group. Despite the FS diet being partially efficient in protecting the ileum against inflammation, the tight junctions were increased, compared to the HF group. The GPR120 and GPR40 receptors were unaffected by diets, but GPR120 was colocalized on the surface of ileum macrophages. The short period of a high-fat diet was enough to start the obesogenic process, ileum inflammation, and reduce the tight junctions. Flaxseed oil did not protect efficiently against dysmetabolism. Still, it increased the tight junctions, even without alteration on inflammatory parameters, suggesting the protection against gut permeability during early obesity development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleo de Semente do Linho / Ácidos Graxos Ômega-3 Limite: Animals / Humans / Male Idioma: En Revista: J Nutr Biochem Assunto da revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleo de Semente do Linho / Ácidos Graxos Ômega-3 Limite: Animals / Humans / Male Idioma: En Revista: J Nutr Biochem Assunto da revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos