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Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.
Ramírez-Coronel, Andrés Alexis; Ali Alhilali, Khetam Abdalsada; Basheer Ahmed, Yasmin; Almalki, Sami G; Karimian, Jahangir.
Afiliação
  • Ramírez-Coronel AA; Azogues Campus Nursing Career, Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Cuenca, Ecuador.
  • Ali Alhilali KA; University of Palermo, Buenos Aires, Argentina.
  • Basheer Ahmed Y; Research group in educational statistics, National University of Education, Azogues, Ecuador.
  • Almalki SG; Epidemiology and Biostatistics Research Group, CES University, Medellín, Colombia.
  • Karimian J; College of Dentistry, Al-Qadisiyah University, Al-Qadisiyah, Iraq.
Phytother Res ; 37(9): 3809-3819, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37317803
Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta-analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta-analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: -28.61 mg/dL, 95% CI: -36.07 to -21.16, p˂0.001; I2 = 98.3%) and HbA1c percentage (WMD: -0.99%, 95% CI: -1.22 to -0.76, p ≤ 0.001; I2 = 65.1%) in patients with T2D. However, sesame consumption did not significantly influence fasting insulin levels (Hedges's: 2.29, 95% CI: -0.06 to 4.63, p = 0.06; I2 = 98.1%). In summary, the current meta-analysis showed a promising effect of sesame consumption on glycemic control through reducing FBS and HbA1c, yet additional prospective studies are recommended, using higher doses and longer intervention period, to confirm the impact of sesame consumption on insulin levels in T2D patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Sesamum / Diabetes Mellitus Tipo 2 / Insulinas Tipo de estudo: Clinical_trials / Observational_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Sesamum / Diabetes Mellitus Tipo 2 / Insulinas Tipo de estudo: Clinical_trials / Observational_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido