Association of amino levulinate dehydratase levels and ferrochelatase inhibition in childhood lead exposure.
J Pediatr
; 109(1): 60-4, 1986 Jul.
Article
em En
| MEDLINE
| ID: mdl-3723241
The basis for the clinical variation in response to lead exposure in children is not well understood. We studied selected children from a large lead screening program in whom elevation of red cell protoporphyrin concentration (a measure of inhibition of the enzyme ferrochelatase) was markedly above or below average for a given blood lead level. We then measured the activity of the enzyme amino levulinate dehydratase in 306 of these children, and found that ALA-d activity was lower in children with higher protoporphyrin elevation, independent of the effects of lead. This observation, coupled with reports in the literature of families with ALA-d deficiencies and elevated red cell protoporphyrin values, makes likely a genetic basis for some of the variation in susceptibility to lead. The mechanism by which the two effects are associated remains unknown.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ferroquelatase
/
Sintase do Porfobilinogênio
/
Chumbo
/
Liases
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
Estados Unidos