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Colloidal copper oxide nanoparticles leading to a biphasic dose-response in growth inhibition of Staphylococcus aureus.
Ferreira, Susana Rs; Lopes, Jefferson Ms; Paterno, Leonardo G; Magalhães, Pérola O; Cunha-Filho, Marcílio; Gelfuso, Guilherme M; Gratieri, Taís.
Afiliação
  • Ferreira SR; Laboratory of Food, Drug, & Cosmetics, School of Health Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Lopes JM; Department of Physics, Federal University of Roraima, Boa Vista, 69310-000, Brazil.
  • Paterno LG; Laboratory of Research on Polymers & Nanomaterials, Institute of Chemistry, Brasilia, Brasília, 70904-970, Brazil.
  • Magalhães PO; Laboratory of Natural Products, Faculty of Health Science, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Cunha-Filho M; Laboratory of Food, Drug, & Cosmetics, School of Health Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Gelfuso GM; Laboratory of Food, Drug, & Cosmetics, School of Health Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Gratieri T; Laboratory of Food, Drug, & Cosmetics, School of Health Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
Future Microbiol ; 18: 471-479, 2023 05.
Article em En | MEDLINE | ID: mdl-37204307
Antibacterial agents are often used to stop the growth of bacteria such as Staphylococcus aureus (S. aureus). Copper oxide nanoparticles (CuO-NP) stand as a promising candidate for this purpose. Generally, the agent´s effectiveness is inspected following a dose-response curve in which de agent´s antibacterial response is plotted against its dose (concentration). In this work, employing an extended mathematical interpretation we were capable of discerning experimentally the existence of two stages of dose-response (biphasic dose-response) in the treatment of S. aureus with CuO-NP. These results in combination with insights from spectroscopic techniques lead to the understanding that the biphasic behavior arises from the aggregation of CuO-NP at high concentrations. Therefore, according to the adopted concentration to treat S. aureus, the agent can behave as a dispersed nanoparticle or as an aggregated nanoparticle. In summary, understanding whether antibacterial agents transform as a function of concentration is important in determining their practical applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Nanopartículas Metálicas Tipo de estudo: Prognostic_studies Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Nanopartículas Metálicas Tipo de estudo: Prognostic_studies Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido