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Design of rapamycin and resveratrol coloaded liposomal formulation for breast cancer therapy.
Dos Reis, Leidiana Rocha; Luiz, Marcela Tavares; Sábio, Rafael M; Marena, Gabriel Davi; Di Filippo, Leonardo Delello; Duarte, Jonatas Lobato; Souza Fernandes, Ligia de; Sousa Araújo, Victor H; Oliveira Silva, Viviane Aline; Chorilli, Marlus.
Afiliação
  • Dos Reis LR; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Luiz MT; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Sábio RM; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Marena GD; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Di Filippo LD; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Duarte JL; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Souza Fernandes L; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Sousa Araújo VH; School of Pharmaceutical Science, Sao Paulo State University (UNESP), Araraquara, SP, 14800-903, Brazil.
  • Oliveira Silva VA; Molecular Oncology Research Center, Barretos Cancer Hospital, Antenor Duarte Villela St, 1331, Barretos, SP, 14784-400, Brazil.
  • Chorilli M; Department of Pathology & Legal Medicine, Medical School of the Federal University of Bahia, BA, 40026-010, Brazil.
Nanomedicine (Lond) ; 18(10): 789-801, 2023 04.
Article em En | MEDLINE | ID: mdl-37199266
Aims: The development of rapamycin (RAP) and resveratrol (RSV) coloaded liposomes (RAP-RSV-LIP) for breast cancer therapy. Materials & methods: Liposomes were prepared using a high-pressure homogenization technique and evaluated according to their physicochemical characteristics, cellular uptake and cytotoxicity against tumoral and normal cells. Results & conclusion: The RAP-RSV-LIP showed negative surface charge, size around 100 nm, low polydispersity and high encapsulation efficiency for RAP and RSV (58.87 and 63.22%, respectively). RAP-RSV-LIP showed great stability over 60 days and a prolonged drug-release profile. In vitro studies indicated that RAP-RSV-LIP were internalized in an estrogen receptor-positive human breast cancer cell line (MCF-7, 34.2%) and improved cytotoxicity when compared with free drugs. Therefore RAP-RSV-LIP showed great antitumoral potential against breast cancer cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Lipossomos Limite: Female / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Lipossomos Limite: Female / Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido