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Characterization and subchronic oral toxicity of Pentaclethra macroloba (pracaxi) oil in Rattus norvegicus (lin. Wistar).
Eberhart, Bruna de Souza; Komiyama, Claudia Marie; Burbarelli, Maria Fernanda de Castro; Castilho Heiss, Vivian Aparecida Rios; Garcia, Rodrigo Garófallo; Borges, Rafael; Felix, Gisele Aparecida; Cardoso, Claudia Andrea Lima; Braz, Paulo Henrique; Teodoro, Cássia Regina; Serpa, Felipe Cardoso; Gandra, Erika Rosendo de Sena.
Afiliação
  • Eberhart BS; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Komiyama CM; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Burbarelli MFC; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Castilho Heiss VAR; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil. Electronic address: viviancastilho@live.com.
  • Garcia RG; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Borges R; Greater Dourados University Center, College of Veterinary Medicine, Dourados, MS, Brazil.
  • Felix GA; Greater Dourados University Center, College of Veterinary Medicine, Dourados, MS, Brazil.
  • Cardoso CAL; State University of Mato Grosso Do Sul, Dourados, MS, Brazil.
  • Braz PH; Federal Institute of Farroupilha, Frederico Westphalen, RS, Brazil.
  • Teodoro CR; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Serpa FC; Federal University of Grande Dourados, Faculty of Agricultural Sciences, Dourados, MS, Brazil.
  • Gandra ERS; Studies Institute of Trópico Úmido, UNIFESSPA, Xinguara, PA, Brazil.
Toxicon ; 230: 107151, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37187226
The trend of replacing antimicrobials as growth promoters in animal nutrition is growing. Functional oils emerge as an alternative because of their richness in bioactive compounds and bioavailability. The present study aims to evaluate the fatty acid profile, antioxidant capacity, composition of phenolic compounds, and toxic capacity in Wistar rats of pracaxi oil (Pentaclethra macroloba). DDPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (Ferric Reducing Antioxidant Power), and ABTS (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) were performed to assess antioxidant capacity. The composition of phenolic compounds was determined by specific reagents. For the evaluation of subchronic oral toxicity, 40 Wistar albino rats (20 males and 20 females) were randomized into 10 groups with different levels of pracaxi oil administered orally. The doses administered were 0, 300, 600, 1200 and 2400 mg/kg (Group 1 to 5 females and Group 6 to 10 males). The animals were submitted to evaluations described in the OECD manual (Guide 407). The analytical results showed that pracaxi oil has different fatty acids in its chemical composition: oleic, linoleic, arachidic, and behenic acids, which account for more than 90% of its composition. In a smaller percentage, lauric acid (0.17%), myristic (0.09%), palmitic (1.49%), stearic (3.45%), and linolenic acid (1.39%) were also found. According to the results of the antioxidant tests, pracaxi oil has a high antioxidant capacity and is a product with a high presence of phenolic compounds. Regarding the toxicity assessment, there were no alterations in the clinical signs and weight of organs. However, in histology, there were mild alterations of a possible toxic process with the increase in the oil dose. This research is extremely valuable since pracaxi oil is a product with little information about its potential use in animal nutrition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Antioxidantes Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Antioxidantes Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido