Amyloidosis and the Kidney: An Update.
Semin Nephrol
; 42(6): 151343, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-37148782
Various types of systemic amyloidosis can wreak havoc on the architecture and functioning of the kidneys. Amyloidosis should be suspected in patients with worsening kidney function, proteinuria, and multisystem involvement, but isolated kidney involvement also is possible. Confirming the amyloidosis type and specific organ dysfunction is of paramount importance to select the appropriately tailored treatment and aim for better survival while avoiding treatment-associated toxicities. Amyloid renal staging in light chain amyloidosis amyloidosis helps inform prognosis and risk for end-stage kidney disease. Biomarker-based staging systems and response assessment guide the therapeutic strategy and allow the timely identification of refractory or relapsing disease so that patients can be switched to salvage therapy. Kidney transplantation is a viable option for selected patients with amyloidosis. Because of the complex nature of the pathophysiology and treatment of amyloidosis, a multidisciplinary team-based approach should be used in the care of these patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Amiloidose
/
Falência Renal Crônica
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Nephrol
Ano de publicação:
2022
Tipo de documento:
Article
País de publicação:
Estados Unidos