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Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension.
Bomfim, Gisele F; Priviero, Fernanda; Poole, Emma; Tostes, Rita C; Sinclair, John H; Stamou, Dimitrios; Uline, Mark J; Wills, Mark R; Webb, R Clinton.
Afiliação
  • Bomfim GF; Institute of Health Sciences, Federal University of Mato Grosso, campus Sinop (UFMT), Sinop, MT, Brazil.
  • Priviero F; Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, USA.
  • Poole E; Cardiovascular Translational Research Center, University of South Carolina, Columbia, South Carolina, USA.
  • Tostes RC; Biomedical Engineering Program, University of South Carolina, Columbia, South Carolina, USA.
  • Sinclair JH; Department of Cell Biology and Anatomy, University of South Carolina, Columbia, South Carolina, USA.
  • Stamou D; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Uline MJ; Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, SP, Brazil.
  • Wills MR; Department of Pathology, University of Cambridge, Cambridge, UK.
  • Webb RC; Department of Medicine, University of Cambridge, Cambridge, UK.
Am J Hypertens ; 36(9): 471-480, 2023 08 05.
Article em En | MEDLINE | ID: mdl-37148218
Cytomegalovirus (CMV) is a member of the ß-herpesviruses and is ubiquitous, infecting 50%-99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclerosis, post-transplant vasculopathy, and hypertension). Herpesviruses, including CMV, encode viral G-protein-coupled receptors (vGPCRs) that alter the host cell by hijacking signaling pathways that play important roles in the viral life cycle and these cardiovascular diseases. In this brief review, we discuss the pharmacology and signaling properties of these vGPCRs, and their contribution to hypertension. Overall, these vGPCRs can be considered attractive targets moving forward in the development of novel hypertensive therapies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Infecções por Citomegalovirus / Hipertensão Limite: Humans Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Infecções por Citomegalovirus / Hipertensão Limite: Humans Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos