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Association of mesenchymal stem cells derived from bone marrow and adipose tissue enhances bone repair in rat calvarial defects.
Campos Totoli, Gabriela Guaraldo; Bighetti-Trevisan, Rayana Longo; Freitas, Gileade Pereira; Adolpho, Leticia Faustino; Golçalves Almeida, Adriana Luisa; Loyola Barbosa, Ana Carolina; Reis Ramos, Jaqueline Isadora; Beloti, Marcio Mateus; Rosa, Adalberto Luiz.
Afiliação
  • Campos Totoli GG; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Bighetti-Trevisan RL; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Freitas GP; School of Dentistry, Federal University of Goiás, Goiânia, GO, 74605-020 Brazil.
  • Adolpho LF; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Golçalves Almeida AL; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Loyola Barbosa AC; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Reis Ramos JI; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Beloti MM; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
  • Rosa AL; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-904, Brazil.
Regen Med ; 18(5): 377-387, 2023 05.
Article em En | MEDLINE | ID: mdl-37125511
We evaluated the bone repair induced by cells that can develop into different types of cells (stem cells) derived from fat and spongy tissue inside the large bones and injected into defects created in rat skulls. Cells derived from both tissues developed into fat cells and bone-forming cells. The combination of cells from fat and spongy tissue exhibited cooperative effects to increase bone repair with an advantage when cells from spongy tissue were injected prior to cells from fat. Our findings may contribute to stablish new therapies based on the use of cells to treat large bone defects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Células-Tronco Mesenquimais Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Regen Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Células-Tronco Mesenquimais Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Regen Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido