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Anti-inflammatory Activity: In silico and In vivo of Sapogenins Present in Agave brittoniana subsp. brachypus (Trel.).
Resino-Ruiz, Dayana; Gonzalez-Madariaga, Yisel; Nieto, Leisy; Linares, Yilka Mena; León, Jose Orestes Guerra; Martín, Arlena Vázquez; Díaz, Arianna Valido; Torrens, Francisco; Castillo-Garit, Juan A.
Afiliação
  • Resino-Ruiz D; Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
  • Gonzalez-Madariaga Y; Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
  • Nieto L; Departamento de Farmacia, Facultad de Química-Farmacia, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.
  • Linares YM; Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
  • León JOG; Departamento de Química, Facultad de Química-Farmacia, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.
  • Martín AV; Departamento de Química, Facultad de Química-Farmacia, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.
  • Díaz AV; Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
  • Torrens F; Institut Universitari de Ciència Molecular, Universitat de València, Edifici d'Instituts de Paterna, P.O. Box 22085, E-46071, València, Spain.
  • Castillo-Garit JA; Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
Antiinflamm Antiallergy Agents Med Chem ; 22(1): 42-48, 2023.
Article em En | MEDLINE | ID: mdl-37114792
BACKGROUND: Agave brittoniana subsp. brachypus is an endemic plant of Cuba, which contains different steroidal sapogenins with anti-inflammatory effects. This work aims to develop computational models which allow the identification of new chemical compounds with potential anti-inflammatory activity. METHODS: The in vivo anti-inflammatory activity was evaluated in two rat models: carrageenaninduced paw edema and cotton pellet-induced granuloma. In each study, we used 30 Sprague Dawley male rats divided into five groups containing six animals. The products isolated and administrated were fraction rich in yuccagenin and sapogenins crude. RESULTS: The obtained model, based on a classification tree, showed an accuracy value of 86.97% for the training set. Seven compounds (saponins and sapogenins) were identified as potential antiinflammatory agents in the virtual screening. According to in vivo studies, the yuccagenin-rich fraction was the greater inhibitor of the evaluated product from Agave. CONCLUSION: The evaluated metabolites of the Agave brittoniana subsp. Brachypus showed an interesting anti-inflammatory effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sapogeninas / Saponinas / Agave Limite: Animals Idioma: En Revista: Antiinflamm Antiallergy Agents Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Cuba País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sapogeninas / Saponinas / Agave Limite: Animals Idioma: En Revista: Antiinflamm Antiallergy Agents Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Cuba País de publicação: Emirados Árabes Unidos