Your browser doesn't support javascript.
loading
Pediatric chronic myeloid leukemia in myeloid blast crisis.
Dey, Biswajit; Dutta, Anirban.
Afiliação
  • Dey B; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Department of Pathology, Shillong, Meghalaya, India.
  • Dutta A; University of Hawaii John A. Burns School of Medicine, Department of Pediatrics, Honolulu, Hawaii, United States of America.
Autops Case Rep ; 13: e2023426, 2023.
Article em En | MEDLINE | ID: mdl-37101551
Chronic myeloid leukemia (CML) accounts for 2-3% of childhood leukemias. About 5% of cases present in a blastic phase of CML which clinically and morphologically mimics more common acute leukemias of childhood. We report a case of a 3-year-old male who presented with gradual onset swelling of the abdomen and extremities along with generalized weakness. Examination revealed massive splenomegaly, pallor, and pedal edema. Initial workup showed anemia, thrombocytopenia, and leukocytosis (120,000/uL) with a blast percentage of 35%. Blasts were positive for CD13, CD33, CD117, CD34 and HLA-DR, and stained negative for Myeloperoxidase and Periodic Acid Schiff. Fluorescence in situ hybridization was positive for b3a2/e14a2 junction BCR-ABL1 transcript and negative for RUNX1-RUNX1T1/t(8;21), clinching the diagnosis of CML in myeloid blast crisis. The patient expired within 17 days of diagnosis and initiation of therapy.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Autops Case Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Autops Case Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil