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A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity.
Ortiz, Geovanny Genaro Reivan; Mohammadi, Yasaman; Nazari, Ahmad; Ataeinaeini, Mehrnaz; Kazemi, Parisa; Yasamineh, Saman; Al-Naqeeb, Bashar Zuhair Talib; Zaidan, Haider Kamil; Gholizadeh, Omid.
Afiliação
  • Ortiz GGR; Laboratory of Basic Psychology, Behavioral Analysis and Programmatic Development (PAD-LAB), Catholic University of Cuenca, Cuenca, Ecuador.
  • Mohammadi Y; Faculty of Dentistry, Islamic Azad University, Shiraz Branch, Shiraz, Iran.
  • Nazari A; Tehran University of Medical Sciences, Tehran, Iran.
  • Ataeinaeini M; Iranian Hospital, Dubai, UAE.
  • Kazemi P; Faculty of Dentistry, Ilam University of Medical Sciences, Ilam, Iran.
  • Yasamineh S; Stem Cell Research Center at, Tabriz University of Medical Sciences, Tabriz, Iran. Yassaman124@gmail.com.
  • Al-Naqeeb BZT; Anesthesia Technology Department, Al-Turath University College, Al Mansour, Baghdad, Iraq.
  • Zaidan HK; Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hillah, Babylon, Iraq.
  • Gholizadeh O; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. ogholizade1374@gmail.com.
Cell Commun Signal ; 21(1): 85, 2023 04 24.
Article em En | MEDLINE | ID: mdl-37095512
Aging is a biological process determined through time-related cellular and functional impairments, leading to a decreased standard of living for the organism. Recently, there has been an unprecedented advance in the aging investigation, especially the detection that the rate of senescence is at least somewhat regulated via evolutionarily preserved genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation over the whole lifetime of an organism. The senescence process influences many of the natural features of HSC, leading to a decline in their capabilities, independently of their microenvironment. New studies show that HSCs are sensitive to age-dependent stress and gradually lose their self-renewal and regeneration potential with senescence. MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally inhibit translation or stimulate target mRNA cleavage of target transcripts via the sequence-particular connection. MiRNAs control various biological pathways and processes, such as senescence. Several miRNAs are differentially expressed in senescence, producing concern about their use as moderators of the senescence process. MiRNAs play an important role in the control of HSCs and can also modulate processes associated with tissue senescence in specific cell types. In this review, we display the contribution of age-dependent alterations, including DNA damage, epigenetic landscape, metabolism, and extrinsic factors, which affect HSCs function during aging. In addition, we investigate the particular miRNAs regulating HSCs senescence and age-associated diseases. Video Abstract.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Longevidade Idioma: En Revista: Cell Commun Signal Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Longevidade Idioma: En Revista: Cell Commun Signal Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Reino Unido