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Fibrosis as a Risk Factor for Cutaneous Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa: A Systematic Review.
de Azevedo, Brenda Lamônica Rodrigues; Roni, Gabriel Marim; Torrelio, Rosalie Matuk Fuentes; da Gama-de-Souza, Letícia Nogueira.
Afiliação
  • de Azevedo BLR; Federal University of Espírito Santo, Health Science Center, Graduate Program in Dental Science, Vitória, ES, Brazil.
  • Roni GM; Federal University of Espírito Santo, Health Science Center, Morphology Department, Medical School, Vitória, ES, Brazil.
  • Torrelio RMF; Plastic Surgery, Our Lady of Glory Children's Hospital, Debra, Vitória, ES, Brazil.
  • da Gama-de-Souza LN; Federal University of Espírito Santo, Health Science Center, Morphology Department, Graduate Program in Dental Science, Vitória, ES, Brazil.
J Pediatr Genet ; 12(2): 97-104, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37090823
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe subtype of epidermolysis bullosa caused by changes in collagen VII with a high risk of early development of cutaneous squamous cell carcinoma (cSCC). This review aimed to discuss the relationship between the recurrent healing process, the appearance of fibrosis, and malignant epithelial transformation in RDEB. We searched PubMed, the Regional Portal of the Virtual Health Library, and Embase for articles on the relationship between blistering, recurrent scarring, and fibrosis in the context of cSCC and RDEB. That alterations of collagen VII result in blister formation, scar deficiency associated with inflammation, and increased expression of transforming growth factor ß. These events promote the differentiation of myofibroblasts and the expression of profibrotic proteins, leading to structural changes and the establishment of a microenvironment favorable to carcinogenesis. Patients with RDEB and areas of recurrent scarring and fibrosis may be more prone to the development of cSCC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J Pediatr Genet Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J Pediatr Genet Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha