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Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs.
Moraes, Renata Delphim de; Araujo Júnior, Edward; Castelo Filho, Adauto; Peixoto, Alberto Borges; Amed, Abês Mahmed.
Afiliação
  • Moraes RD; Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Araujo Júnior E; Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Castelo Filho A; Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Peixoto AB; Universidade de Uberaba, Uberaba, MG, Brazil.
  • Amed AM; Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo) ; 21: eAO0230, 2023.
Article em En | MEDLINE | ID: mdl-37075461
OBJECTIVE: • No drug related fetal malformations. • No adverse effects on vital organ functions. To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses. METHODS: Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 (12mg/kg/day enfuvirtide), and G3 (36mg/kg/day enfuvirtide) groups. On the 20th day of gestation, the rats were anesthetized and subjected to cesarean section. Their blood was collected for laboratory analysis, and they were sacrificed. The offspring's fragments of their kidneys, liver, and placentas and the maternal rats' fragments of their lungs, kidneys, and liver were separated in the immediate postpartum period for light microscopy analysis. RESULTS: No maternal deaths occurred. In the second week at the end of pregnancy, the mean weight of the G3 Group was significantly lower than that of the G2 Group (p=0.029 and p=0.028, respectively). Analyzing blood laboratory parameters, the G1 Group had the lowest mean amylase level, and the G2 Group had the lowest mean hemoglobin level and the highest mean platelet count. In the morphological analysis, there were no changes in organs, such as the kidneys and liver, in both the maternal rats and offspring. Three maternal rats in the G3 Group had pulmonary inflammation in the lungs. CONCLUSION: Enfuvirtide has no significant adverse effects on pregnancy, conceptual products, or functional alterations in maternal rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Roedores / Cesárea Limite: Animals / Pregnancy Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Roedores / Cesárea Limite: Animals / Pregnancy Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil