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Short-chain fatty acids are associated with adiposity, energy and glucose homeostasis among different metabolic phenotypes in the Nutritionists' Health Study.
Solar, Isabela; Ribeiro, Francieli Barreiro; Barbosa, Marina Gomes; de Oliveira Nascimento Freitas, Renata Germano Borges; Hanada, Alfredo Shigueo; de Oliveira Ramos, Camila; Sant'Ana, Marcella Ramos; Candreva, Thamiris; de Almeida-Pititto, Bianca; Tura, Andrea; Cintra, Dennys Esper; Geloneze, Bruno; Ferreira, Sandra Roberta Gouvea; Vasques, Ana Carolina Junqueira.
Afiliação
  • Solar I; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
  • Ribeiro FB; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Barbosa MG; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • de Oliveira Nascimento Freitas RGB; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
  • Hanada AS; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • de Oliveira Ramos C; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
  • Sant'Ana MR; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
  • Candreva T; Laboratory of Investigation on Metabolism and Diabetes, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • de Almeida-Pititto B; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
  • Tura A; Nutritional Genomics Laboratory, School of Applied Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Cintra DE; Nutritional Genomics Laboratory, School of Applied Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Geloneze B; School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
  • Ferreira SRG; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
  • Vasques ACJ; Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.
Endocrine ; 80(3): 529-540, 2023 06.
Article em En | MEDLINE | ID: mdl-37029854
BACKGROUND AND AIMS: The gut microbiome is associated with obesity, mainly mediated by bacteria-produced short-chain fatty acids (SCFAs). It is unknown how SCFA concentrations are associated with the phenotypes metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy obese/overweight (MHO), and metabolically unhealthy obese/overweight (MUO). We compared plasma and fecal SCFA concentrations among adult women categorized according to the metabolic phenotypes mentioned above and examined associations between SCFA and adiposity and components of energy and glucose homeostasis. METHODS: This was a cross-sectional study involving 111 participants. Body composition was assessed by DEXA. Energy and glycemic homeostasis were assessed by the standard mixed-meal tolerance test coupled with indirect calorimetry. SCFAs were quantified by gas chromatography and mass spectrometry. RESULTS: Only plasma propionate was increased in the MHNW phenotype compared to the MHO and MUO phenotypes [p < 0.05]. Fecal propionate and butyrate concentrations and plasma propionate concentrations were inversely associated with total and visceral adiposity [p < 0.05]. Fecal and plasma SCFA concentrations were associated with reduced glucose, insulin and HbA1c levels, increased fasting and postprandial GLP-1 levels; and more preserved beta-cell function [p < 0.05]. Fecal and plasma SCFA concentrations were positively correlated with resting energy expenditure and lipid oxidation rate and inversely correlated with the oxidation rate of carbohydrates [p < 0.05]. CONCLUSION: These findings reinforce the concept that fecal and plasma SCFA concentrations are linked to specific components of energy and glucose homeostasis; and body adiposity. However, it was not possible to discriminate the different metabolic phenotypes of adiposity based on the determination of fecal SCFA concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Nutricionistas Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Endocrine Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Nutricionistas Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Endocrine Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos