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Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis.
Monteiro, Elisa B; Ajackson, Matheus; Stockler-Pinto, Milena B; Guebre-Egziabher, Fitsum; Daleprane, Julio B; Soulage, Christophe O.
Afiliação
  • Monteiro EB; Nutrition and Genomics Laboratory, Basic and Experimental Nutrition Department, Institute of Nutrition, Rio de Janeiro State University, 20550-900 Rio de Janeiro, Brazil.
  • Ajackson M; Nutrition and Genomics Laboratory, Basic and Experimental Nutrition Department, Institute of Nutrition, Rio de Janeiro State University, 20550-900 Rio de Janeiro, Brazil.
  • Stockler-Pinto MB; Graduate Program in Pathology, Federal Fluminense University (UFF), Niterói, RJ, Brazil; Graduate Program in Nutrition Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.
  • Guebre-Egziabher F; Hospices Civils de Lyon, Department of Nephrology, Hôpital E Herriot, Lyon F-69003, France; Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA-Lyon, Université Claude Bernard Lyon 1, 69500, Bron, France.
  • Daleprane JB; Nutrition and Genomics Laboratory, Basic and Experimental Nutrition Department, Institute of Nutrition, Rio de Janeiro State University, 20550-900 Rio de Janeiro, Brazil.
  • Soulage CO; Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA-Lyon, Université Claude Bernard Lyon 1, 69500, Bron, France. Electronic address: christophe.soulage@univ-lyon1.fr.
Life Sci ; 322: 121664, 2023 Jun 01.
Article em En | MEDLINE | ID: mdl-37023957
AIMS: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, has received extensive attention as a natural activator of the Nrf2/Keap1 cytoprotective pathway. In this review, a meta-analysis and systematic review of the renoprotective effects of SFN were performed in various preclinical models of kidney diseases. MAIN METHODS: The primary outcome was the impact of SFN on renal function biomarkers (uremia, creatininemia, proteinuria or creatinine clearance) and secondary outcomes were kidney lesion histological indices/kidney injury molecular biomarkers. The effects of SFN were evaluated according to the standardized mean differences (SMDs). A random-effects model was applied to estimate the overall summary effect. KEY FINDINGS: Twenty-five articles (out of 209 studies) were selected from the literature. SFN administration significantly increased creatinine clearance (SMD +1.88 95 % CI: [1.09; 2.68], P < 0.0001, I2 = 0 %) and decreased the plasma creatinine (SMD -1.24, [-1.59; -0.88], P < 0.0001, I2 = 36.0 %) and urea (SMD -3.22 [-4.42, -2.01], P < 0.0001, I2 = 72.4 %) levels. SFN administration (median dose: 2.5 mg/kg, median duration: 3 weeks) significantly decreased urinary protein excretion (SMD -2.20 [-2.68; -1.73], P < 0.0001, I2 = 34.1 %). It further improved two kidney lesion histological indices namely kidney fibrosis (SMD -3.08 [-4.53; -1.63], P < 0.0001, I2 = 73.7 %) and glomerulosclerosis (SMD -2.24 [-2.96; -1.53], P < 0.0001, I2 = 9.7 %) and decreased kidney injury molecular biomarkers (SMD -1.51 [-2.00; -1.02], P < 0.0001, I2 = 0 %). SIGNIFICANCE: These findings provide new insights concerning preclinical strategies for treating kidney disease or kidney failure with SFN supplements and should stimulate interest in clinical evaluations of SFN in patients with kidney disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Nefropatias Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Nefropatias Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda