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Ion Channels-related Neuroprotection and Analgesia Mediated by Spider Venom Peptides.
Nogueira Souza, Ana Caroline; Binda, Nancy Scardua; Almeida, Huemara Yuri; de Castro Júnior, Célio José; Gomez, Marcus Vinicius; Ribeiro, Fabíola Mara; Da Silva, Juliana Figueira.
Afiliação
  • Nogueira Souza AC; Center of Technology in Molecular Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Binda NS; Department of Pharmacy, Federal University of Ouro Preto (UFOP), Ouro Preto, MG, Brazil.
  • Almeida HY; Department of Pharmacy, Federal University of Ouro Preto (UFOP), Ouro Preto, MG, Brazil.
  • de Castro Júnior CJ; Department of Health Sciences, Institute of Education and Research, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
  • Gomez MV; Department of Health Sciences, Institute of Education and Research, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
  • Ribeiro FM; Department of Biochemistry and Immunology, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Da Silva JF; Department of Pharmacy, Federal University of Ouro Preto (UFOP), Ouro Preto, MG, Brazil.
Curr Protein Pept Sci ; 24(5): 365-379, 2023.
Article em En | MEDLINE | ID: mdl-37018532
Ion channels play critical roles in generating and propagating action potentials and in neurotransmitter release at a subset of excitatory and inhibitory synapses. Dysfunction of these channels has been linked to various health conditions, such as neurodegenerative diseases and chronic pain. Neurodegeneration is one of the underlying causes of a range of neurological pathologies, such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, brain injury, and retinal ischemia. Pain is a symptom that can serve as an index of the severity and activity of a disease condition, a prognostic indicator, and a criterion of treatment efficacy. Neurological disorders and pain are conditions that undeniably impact a patient's survival, health, and quality of life, with possible financial consequences. Venoms are the best-known natural source of ion channel modulators. Venom peptides are increasingly recognized as potential therapeutic tools due to their high selectivity and potency gained through millions of years of evolutionary selection pressure. Spiders have been evolving complex and diverse repertoires of peptides in their venoms with vast pharmacological activities for more than 300 million years. These include peptides that potently and selectively modulate a range of targets, such as enzymes, receptors, and ion channels. Thus, components of spider venoms hold considerable capacity as drug candidates for alleviating or reducing neurodegeneration and pain. This review aims to summarize what is known about spider toxins acting upon ion channels, providing neuroprotective and analgesic effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Venenos de Aranha / Aranhas / Analgesia Tipo de estudo: Prognostic_studies Aspecto: Patient_preference Limite: Animals Idioma: En Revista: Curr Protein Pept Sci Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Venenos de Aranha / Aranhas / Analgesia Tipo de estudo: Prognostic_studies Aspecto: Patient_preference Limite: Animals Idioma: En Revista: Curr Protein Pept Sci Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos