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Mapping the modulating effect of transcutaneous auricular vagus nerve stimulation on voxel-based analyses in patients with first-episode major depressive disorder: a resting-state functional magnetic resonance imaging study.
He, Jia-Kai; Li, Shao-Yuan; Wang, Yu; Zhao, Bin; Xiao, Xue; Hou, Xiao-Bing; Zhang, Shuai; Zhao, Ya-Nan; Zhai, Wei-Hang; Fang, Ji-Liang; Rong, Pei-Jing.
Afiliação
  • He JK; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China. Department of Traditional Chinese Medicine, Peking University People's Hospital, Beijing, China.
  • Li SY; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
  • Wang Y; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
  • Zhao B; Department of Acupuncture, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • Xiao X; Department of Psychiatry, Beijing First Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China.
  • Hou XB; Department of Psychiatry, Beijing First Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China.
  • Zhang S; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
  • Zhao YN; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
  • Zhai WH; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
  • Fang JL; Department of Radiology, Guang'anmen Hospital, CACMS, Beijing, China.
  • Rong PJ; Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.
Braz J Psychiatry ; 45(2): 93-101, 2023 May 11.
Article em En | MEDLINE | ID: mdl-37015869
INTRODUCTION: Seed-based analysis has shown that transcutaneous auricular vagus nerve stimulation (taVNS) can modulate the dysfunctional brain network in patients with major depressive disorder (MDD). However, the voxel-based neuropsychological mechanism of taVNS on patients with first-episode MDD is poorly understood. The objective of this study was to assess the effects of an 8-week course of taVNS on patients with first-episode MDD. METHODS: Twenty-two patients with first-episode MDD accepted an 8-week course of taVNS treatment. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed before and after treatment. Voxel-based analyses were performed to characterize spontaneous brain activity. Healthy controls (n=23) were recruited to minimize test-retest effects. Analysis of covariance (ANCOVA) was performed to ascertain treatment-related changes. Then, correlations between changes in brain activity and the Hamilton Depression Rating Scale (HAM-D)/Hamilton Anxiety Scale (HAM-A) remission rate were estimated. RESULTS: Significant group-by-time interactions on voxel-based analyses were observed in the inferior ventral striatum (VSi) and precuneus. Post-hoc analyses showed that taVNS inhibited higher brain activity in the VSi, while upregulating it in the precuneus. Functional connectivity (FC) between the VSi and precuneus decreased. Positive correlations were found between the HAM-D remission rate and changes in brain activity in the VSi. CONCLUSION: taVNS reduced the FC between VSi and precuneus by normalizing the abnormal spontaneous brain activity of VSi in first-episode MDD patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Elétrica Nervosa Transcutânea / Transtorno Depressivo Maior / Estimulação do Nervo Vago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Elétrica Nervosa Transcutânea / Transtorno Depressivo Maior / Estimulação do Nervo Vago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Brasil