Sequencing errors in Native American mitogenomes: Impact on clade definitions, haplogroup assignation, and beyond.

Aquilano, Eliana; de la Fuente, Constanza; Rodríguez Golpe, Daniela; Motti, Josefina M B; Bravi, Claudio M

Aquilano, Eliana; de la Fuente, Constanza; Rodríguez Golpe, Daniela; Motti, Josefina M B; Bravi, Claudio M.

Afiliação

Aquilano E; Instituto Multidisciplinario de Biología Celular (IMBICE), CCT La Plata CONICET-CICPBA-Universidad Nacional de La Plata, Calle 526 e/ 10 y 11, 1900 La Plata, Argentina.
de la Fuente C; Deparment of Human Genetics, University of Chicago, Chicago, IL, USA.
Rodríguez Golpe D; Instituto Multidisciplinario de Biología Celular (IMBICE), CCT La Plata CONICET-CICPBA-Universidad Nacional de La Plata, Calle 526 e/ 10 y 11, 1900 La Plata, Argentina.
Motti JMB; Laboratorio de Ecología Evolutiva Humana (LEEH), Facultad de Ciencias Sociales (FACSO), Universidad Nacional del Centro de la Provincia de Buenos Aires-CONICET, Calle 508 #881, 7631 Quequén, Argentina.
Bravi CM; Instituto Multidisciplinario de Biología Celular (IMBICE), CCT La Plata CONICET-CICPBA-Universidad Nacional de La Plata, Calle 526 e/ 10 y 11, 1900 La Plata, Argentina. Electronic address: cmbravi@fcnym.unlp.edu.ar.

Mitochondrion ; 70: 54-58, 2023 05.

Article em En | MEDLINE | ID: mdl-37003527

RESUMO

Available evidence allows the interpretation that some cases of absence of otherwise expected variation, based on phylogenetic expectations in mitogenomes of Native American origin, are due to artificial recombination rather than to homoplasy, while other more complex scenarios involving combination of original Cambridge Reference Sequence mistakes plus incomplete or incorrect scoring of variation are also showed. Several instances of mismatched control and coding regions as well as partially duplicated HV2 are observed in Peruvians, while intra-haplogroup chimaeras of different D1 subhaplogroups are referred to in Mexican Native Americans. A revised definition for haplogroup B2h is proposed, and preventive quality control measures are suggested.

Assuntos

Indígena Americano ou Nativo do Alasca; Genoma Mitocondrial; Humanos; Filogenia; Haplótipos; DNA Mitocondrial

Palavras-chave

Artificial recombination; Haplogroup; Mitochondrial DNA; Mitogenome; Native American

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indígena Americano ou Nativo do Alasca / Genoma Mitocondrial Limite: Humans Idioma: En Revista: Mitochondrion Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda

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