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Anti-Inflammatory, Antimicrobial, Antioxidant and Photoprotective Investigation of Red Propolis Extract as Sunscreen Formulation in Polawax Cream.
Valverde, Thalita Marcolan; Soares, Bruna Nayane Goncalves de Souza; Nascimento, Andréa Mendes do; Andrade, Ângela Leão; Sousa, Lucas Resende Dutra; Vieira, Paula Melo de Abreu; Santos, Vagner Rodrigues; Seibert, Janaína Brandão; Almeida, Tatiane Cristine Silva de; Rodrigues, Caio Fabrini; Oliveira, Samantha Roberta Machado de; Martins, Flaviano Dos Santos; Júnior, Jeronimo Geraldo Ferreira; Santos, Viviane Martins Rebello Dos.
Afiliação
  • Valverde TM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
  • Soares BNGS; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Nascimento AMD; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Andrade ÂL; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Sousa LRD; Laboratory of Morphopathology, Center for Research in Biological Sciences, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Vieira PMA; Laboratory of Morphopathology, Center for Research in Biological Sciences, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Santos VR; Laboratory of Microbiology and Biomaterials, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
  • Seibert JB; Natural Products Laboratory, Department of Chemistry, Federal University of São Carlos (UFSCAR), São Carlos 13565-905, SP, Brazil.
  • Almeida TCS; Nuclear Technology Development Center, Belo Horizonte 6627, MG, Brazil.
  • Rodrigues CF; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
  • Oliveira SRM; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
  • Martins FDS; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
  • Júnior JGF; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
  • Santos VMRD; Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil.
Int J Mol Sci ; 24(6)2023 Mar 07.
Article em En | MEDLINE | ID: mdl-36982196
Many activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently, propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic industries, motivating a better understanding of its antioxidant and anti-inflammatory activities. Propolis and its main polyphenolic compounds presented high antioxidant activity, and effectiveness as broad spectrum UVB and UVA photoprotection sunscreens. Through a qualitative phytochemical screening, the ethanolic red propolis extracts (EEPV) (70% at room temperature and 70% at a hot temperature) presented a positive result for flavonoids and terpenoids. It presented an antioxidant activity for reducing 50% of DPPH of 17 and 12 µg/mL for extraction at room temperature and at a hot temperature, respectively. The UPLC-QTOF-MS/MS analysis allowed the annotation of 40 substances for EEPV-Heated and 42 substances for EEPV-Room Temperature. The IC50 results of the ABTS scavenging activity was 4.7 µg/mL for both extractions, at room temperature and at a hot temperature. Additionally, we also evaluated the cytotoxic profile of propolis extracts against macrophage (RAW 264.7 cells) and keratinocytes (HaCaT cells), which showed non-cytotoxic doses in cell viability assays even after a long period of exposure. In addition, propolis extracts showed antibacterial activity for Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), demonstrating potential biological activity for the creation of formulations aimed at disease control and prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Ascomicetos / Anti-Infecciosos Tipo de estudo: Qualitative_research Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Ascomicetos / Anti-Infecciosos Tipo de estudo: Qualitative_research Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça