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The Burkholderia contaminans prevalent phenotypes as possible markers of poor clinical outcomes in chronic lung infection of children with cystic fibrosis.
León, Beltina; Prieto, Claudia; Bettiol, Marisa; Leguizamón, Mariana; D Alessandro, Virginia; Casco, Daniela; Vita, Carolina; Figoli, Cecilia Beatriz; Vescina, Cecilia; Rentería, Fernando; Cardona, Silvia T; Bosch, Alejandra.
Afiliação
  • León B; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • Prieto C; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • Bettiol M; Sala de Microbiología, Hospital de Niños de La Plata "Sor María Ludovica", Calle 14 N° 1631, CP 1900, La Plata, Provincia de Buenos Aires, Argentina.
  • Leguizamón M; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • D Alessandro V; Servicio de Neumonología Hospital de Niños de La Plata "Sor María Ludovica", Calle 14 N° 1631, CP 1900, La Plata, Provincia de Buenos Aires, Argentina.
  • Casco D; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • Vita C; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • Figoli CB; Laboratorio de Biofilms Microbianos, CINDEFI-CONICET, CCT La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 50 N° 227, CP 1900 La Plata, Provincia de Buenos Aires, Argentina.
  • Vescina C; Sala de Microbiología, Hospital de Niños de La Plata "Sor María Ludovica", Calle 14 N° 1631, CP 1900, La Plata, Provincia de Buenos Aires, Argentina.
  • Rentería F; Servicio de Neumonología Hospital de Niños de La Plata "Sor María Ludovica", Calle 14 N° 1631, CP 1900, La Plata, Provincia de Buenos Aires, Argentina.
  • Cardona ST; Department of Microbiology, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.
  • Bosch A; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Chancellors Cir, Winnipeg, MB R3T 2N2, Canada.
Pathog Dis ; 812023 01 17.
Article em En | MEDLINE | ID: mdl-36963774
Burkholderia contaminans, a species of the Burkholderia cepacia complex-prevalent in certain Latin-American and European countries-can cause chronic pulmonary infection in persons with cystic fibrosis. Our aim was to gain insights into long-term lung infections with a focus on correlating how bacterial phenotypic traits in the chronic infection impact on patients' clinical outcome. Genotypic characteristics of 85 B. contaminans isolates recovered from 70 patients were investigated. For 16 of those patients, the clinical status and bacterial phenotypic characteristics, e.g. several virulence factors, phenotypic variants, and the antimicrobial susceptibility pattern, were evaluated. Two clones were found in the whole bacterial population: (i) the multiresistant ST 872 PCR-recA-RFLP-HaeIII-K-pattern clone, which carries a pathogenic island homologous to BcenGI11 of B. cenocepacia J2315, and (ii) the ST 102 PCR-recA-RFLP-HaeIII-AT-pattern clone. The emergence of certain bacterial phenotypes in the chronic infection such as the nonmucoid phenotype, small colony variants, brownish pigmented colonies, and hypermutators, proved to be, together with coinfection with Pseudomonas aeruginosa, the possible markers of more challenging infections and poor prognosis. The presence of cocolonizers and the bacterial phenotypes that are especially adapted to persist in long-term respiratory tract infections have a crucial role in patients' clinical outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Infecções por Burkholderia / Fibrose Cística / Complexo Burkholderia cepacia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Pathog Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Infecções por Burkholderia / Fibrose Cística / Complexo Burkholderia cepacia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Pathog Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos