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Relationship between HuR and tumor drug resistance.
Ma, Qiancheng; Lu, Qiliang; Lei, Xiangxiang; Zhao, Jie; Sun, Wen; Huang, Dongsheng; Zhu, Qing; Xu, Qiuran.
Afiliação
  • Ma Q; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
  • Lu Q; Qingdao Medical College, Qingdao University, Qingdao, 266000, China.
  • Lei X; Hangzhou Medical College, Hangzhou, 310053, China.
  • Zhao J; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
  • Sun W; Zhejiang Chinese Medical University, Hangzhou, 310053, China.
  • Huang D; The Key Laboratory of Tumor Molecular Diagnosis, and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. dshuang@hmc.edu.cn.
  • Zhu Q; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
  • Xu Q; The Key Laboratory of Tumor Molecular Diagnosis, and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. windway626@sina.com.
Clin Transl Oncol ; 25(7): 1999-2014, 2023 Jul.
Article em En | MEDLINE | ID: mdl-36947360
Human resistance protein R (HuR), also known as embryonic lethal abnormal visual-like protein (ELAVL1), is an RNA-binding protein widely expressed in vivo that affects the mRNA stability of targeted and is involved in post-transcriptional regulation. Recent studies have shown that HuR is aberrantly expressed in different human cancers and is an essential factor in poor clinical prognosis. The role of HuR in numerous tumors suggests that it could be a new target for tumor therapy and as a marker for efficacy and prognostic assessment. This review focuses on the relationship between HuR and drug resistance in different tumors and briefly describes the structure, function, and inhibitors of HuR. We summarize the mechanisms by which HuR causes tumor resistance and the molecular targets affected.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Semelhante a ELAV 1 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Itália
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Semelhante a ELAV 1 / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Itália