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Lymphomatoid Papulosis "Type E" Affecting the Palate: A Detailed Case Report and Review of Literature.
Silveira, Heitor Albergoni; Ragusa Silva, Paula Verona; Pimentel, Bruna Gonçalves; Nogueira, Gustavo Milhomens; Chahud, Fernando; Brunaldi, Mariângela Ottoboni; León, Jorge Esquiche.
Afiliação
  • Silveira HA; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, Brazil.
  • Ragusa Silva PV; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil; and.
  • Pimentel BG; Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (UNESP), Araraquara, Brazil.
  • Nogueira GM; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil; and.
  • Chahud F; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil; and.
  • Brunaldi MO; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • León JE; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Am J Dermatopathol ; 45(5): 326-329, 2023 May 01.
Article em En | MEDLINE | ID: mdl-36939130
ABSTRACT: Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30 + lymphoproliferative disorders, characterized by chronic, recurrent, self-healing papules, small nodules, or ulcers. The clinicopathological features of LyP can mimic overt lymphomas. To date, about 27 intraoral LyP cases have been reported. Of them, only 2 cases were diagnosed as angioinvasive LyP (type E). Herein, we report a 24-year-old Brazilian man who presented a large ulcerated lesion on the hard palate with rapid evolution. Remarkably, there was no involvement of the skin or other mucous membranes. Microscopy revealed a lymphoid infiltrate constituted by medium-sized to large atypical cells, with angiocentric and angiodestructive features. The atypical cells showed immunopositivity for CD3, CD8, CD30, CD56, granzyme B, perforin, and focally for MUM1/IRF4. Ki-67 highlighted almost all atypical lymphoid cells, whereas EBER1/2 was negative. After 2 months of follow-up, the lesion healed completely. Although rare, LyP type E should be included in the differential diagnosis of oral ulcers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Papulose Linfomatoide Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Am J Dermatopathol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Papulose Linfomatoide Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Am J Dermatopathol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos