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Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring.
Ogo, Fernanda Mithie; Siervo, Glaucia Eloisa Munhoz Lion; Praxedes, Ana Maria; Vieira, Henrique Rodrigues; da Silva Scarton, Suellen Ribeiro; Bitencourt, Ana Tereza Guimarães; Arena, Arielle Cristina; Simão, Andréa Name Colado; Guerra, Marina Trevizan; de Freitas Mathias, Paulo Cesar; Fernandes, Glaura Scantamburlo Alves.
Afiliação
  • Ogo FM; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • Siervo GEML; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • Praxedes AM; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • Vieira HR; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • da Silva Scarton SR; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Bitencourt ATG; Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Arena AC; Department of General Biology, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • Simão ANC; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina - UEL, Londrina, Brazil.
  • Guerra MT; Department of Biological and Health Sciences, State University of Western Parana, Cascavel, Brazil.
  • de Freitas Mathias PC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - Botucatu (UNESP), Botucatu, Brazil.
  • Fernandes GSA; Department of Pathology, Clinical Analysis and Toxicology, Health Center, State University of Londrina - UEL, Londrina, Brazil.
Birth Defects Res ; 115(7): 710-721, 2023 04 15.
Article em En | MEDLINE | ID: mdl-36929866
INTRODUCTION: It has been suggested that maternal exposure to constant light during the gestational period could be considered as a chronic stressor, impairing offspring development by interfering in neuroendocrine and behavior responses. OBJECTIVE: This study aimed to evaluate whether maternal exposure to continuous light during pregnancy affects the adult reproductive system in the female offspring. MATERIALS AND METHODS: Pregnant Wistar rats were allocated into light-dark (LD) group, exposed to light and dark photoperiod during gestation, and the light-light (LL) group, exposed to a photoperiod of constant light during gestation. After birth, pups were maintained under normal light-dark photoperiod until adulthood. At postnatal day 90, blood was collected from the female offspring, to analyze plasma luteinizing hormone (LH) and progesterone levels, and the uterus and ovaries were harvested for morphometric, histological, and oxidative stress evaluations. RESULTS AND DISCUSSION: Female exposure to continuous light during the intrauterine period resulted in the adult reduction of LH and increased progesterone plasma levels, and uterine injuries a higher number of endometrial glands and reduced levels of antioxidant enzymes, such as glutathione reductase and glutathione S-transferase. In these experimental conditions, gestational continuous light exposure disturbs sex hormone balance and reduces the antioxidant enzymatic activity in the uterus of female offspring in adult life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progesterona / Antioxidantes Limite: Animals / Pregnancy Idioma: En Revista: Birth Defects Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progesterona / Antioxidantes Limite: Animals / Pregnancy Idioma: En Revista: Birth Defects Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos