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Dose-response effect of Montelukast on post-extraction dental socket repair and skeletal phenotype of mice.
Ribeiro, Kim Henderson Carmo; da Silva, Raquel Barroso Parra; Roseno, Ana Carolyna Becher; Barreto, Ana Julia Moreno; Bacelar, Ana Carolina Zucon; Ervolino, Edilson; Duarte, Marco Antônio Húngaro; Fakhouri, Walid D; Chaves-Neto, Antonio Hernandes; Biguetti, Cláudia Cristina; Matsumoto, Mariza Akemi.
Afiliação
  • Ribeiro KHC; Department of Oral Surgery and Dental Clinics, Araçatuba School of Dentistry, São Paulo State University-Unesp, Rua José Bonifácio 1192, Araçatuba, São Paulo, CEP 160188-05, Brazil.
  • da Silva RBP; Department of Oral Surgery and Dental Clinics, Araçatuba School of Dentistry, São Paulo State University-Unesp, Rua José Bonifácio 1192, Araçatuba, São Paulo, CEP 160188-05, Brazil.
  • Roseno ACB; Department of Basic Sciences, Araçatuba School of Dentistry, SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, CEP 160188-05, Araçatuba, São Paulo, Brasil.
  • Barreto AJM; Department of Basic Sciences, Araçatuba School of Dentistry, SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, CEP 160188-05, Araçatuba, São Paulo, Brasil.
  • Bacelar ACZ; Department of Oral Surgery and Dental Clinics, Araçatuba School of Dentistry, São Paulo State University-Unesp, Rua José Bonifácio 1192, Araçatuba, São Paulo, CEP 160188-05, Brazil.
  • Ervolino E; Department of Basic Sciences, Araçatuba School of Dentistry, SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, CEP 160188-05, Araçatuba, São Paulo, Brasil.
  • Duarte MAH; Department of DentistryEndodontics and Dental MaterialsSchool of Dentistry, University of São Paulo, Alameda Otávio Pinheiro Brisola, 9-20, BauruBauru, São Paulo, CEP 7012-901, Brazil.
  • Fakhouri WD; School of Dentistry, The University of Texas at Health Science Center at Houston (UTH), 1941 East Road, Houston, TX, 77054, USA.
  • Chaves-Neto AH; Department of Basic Sciences, Araçatuba School of Dentistry, SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, CEP 160188-05, Araçatuba, São Paulo, Brasil.
  • Biguetti CC; School of Podiatric Medicine, The University of Texas at Rio Grande Valley (UTRGV), 2120 Treasure Hills Blvd. Harlingen, Harlingen, TX, 78550, USA.
  • Matsumoto MA; Department of Basic Sciences, Araçatuba School of Dentistry, SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, CEP 160188-05, Araçatuba, São Paulo, Brasil. mariza.matsumoto@unesp.br.
Odontology ; 111(4): 891-903, 2023 Oct.
Article em En | MEDLINE | ID: mdl-36920595
Bone metabolism and repair are directly regulated by arachidonic acid metabolites. At present, we analyzed the dose-response effects of a selective cysteinyl leukotriene receptor type-1 antagonist during bone repair after tooth extraction and on non-injured skeleton. Sixty-three 129 Sv/Ev male mice composed the groups: C-Control (saline solution); MTK2-2 mg/Kg of Montelukast (MTK) and MTK4-4 mg/Kg of MTK, daily administered by mouth throughout all experimental periods set at 7, 14, and 21 days post-operative. Dental sockets were analyzed by computed microtomography (microCT), histopathology, and immunohistochemistry. Femurs, L5 vertebra and organs were also removed for observation. Blood was collected for plasma bone and liver markers. Histopathology and microCT analysis revealed early socket repair of MTK2 and MTK4 animals, with significant increased BV/TV at days 14 and 21 compared to C. Higher plasma calcium was detected at days 7 and 21 in MTK4 in comparison to C, while phosphate was significantly increased in MTK2 in the same periods in comparison to C and MTK4. No significant differences were found regarding plasma ALP and TRAP, neither for local TRAP and Runx2 immunolabeling at the healing sockets. Organs did not present histological abnormalities. Increased AST levels have been detected in distinct groups and periods. In general, femur phenotype was improved in MTK treated animals. Collectively, MTK promoted early bone formation after tooth extraction and increased bone quality of femurs and vertebra in a time-dose-dependent manner, and should be considered as an alternative therapy when improved post-extraction socket repair or skeleton preservation is required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Alvéolo Dental Limite: Animals Idioma: En Revista: Odontology Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cicatrização / Alvéolo Dental Limite: Animals Idioma: En Revista: Odontology Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Japão