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Multiparity and Aging Impact Chondrogenic and Osteogenic Potential at Symphyseal Enthesis: New Insights into Interpubic Joint Remodeling.
de Sousa, Lizandra Maia; Castelucci, Bianca Gazieri; Suarez, Paula Andrea Saenz; Damas, Ingrid Iara; Mariano, Fernanda Viviane; Joazeiro, Paulo Pinto; Consonni, Sílvio Roberto.
Afiliação
  • de Sousa LM; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Castelucci BG; Laboratory of Immunometabolism, Department of Genetic, Evolution, Microbiology and Immunology, Institute of Biology (IB), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Suarez PAS; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Damas II; Laboratory of Molecular Pathology, Department of Pathology, Division of Pathological Anatomy, School of Medical Sciences (FCM), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Mariano FV; Laboratory of Molecular Pathology, Department of Pathology, Division of Pathological Anatomy, School of Medical Sciences (FCM), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Joazeiro PP; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
  • Consonni SR; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), State University of Campinas (Unicamp), Campinas 13083-970, Brazil.
Int J Mol Sci ; 24(5)2023 Feb 26.
Article em En | MEDLINE | ID: mdl-36902004
Pregnancy and childbirth cause adaptations to the birth canal to allow for delivery and fast recovery. To accommodate delivery through the birth canal, the pubic symphysis undergoes changes that lead to the interpubic ligament (IpL) and enthesis formation in primiparous mice. However, successive deliveries influence joint recovery. We aimed to understand tissue morphology and chondrogenic and osteogenic potential at symphyseal enthesis during pregnancy and postpartum in primiparous and multiparous senescent female mice. Morphological and molecular differences were found at the symphyseal enthesis among the study groups. Despite the apparent incapacity to restore cartilage in multiparous senescent animals, the symphyseal enthesis cells are active. However, these cells have reduced expression of chondrogenic and osteogenic markers and are immersed in densely packed collagen fibers contiguous to the persistent IpL. These findings may indicate alterations of key molecules in the progenitor cell population maintenance of the chondrocytic and osteogenic lineages at the symphyseal enthesis in multiparous senescent animals, possibly compromising the mouse joint histoarchitecture recovery. This sheds light on the distention of the birth canal and the pelvic floor that may play a role in pubic symphysis diastasis (PSD) and pelvic organ prolapse (POP), both in orthopedic and urogynecological practice in women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sínfise Pubiana / Período Pós-Parto Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sínfise Pubiana / Período Pós-Parto Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça