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Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19.
Arrifano, Gabriela de Paula; Augusto-Oliveira, Marcus; Lopes-Araújo, Amanda; Santos-Sacramento, Letícia; Macchi, Barbarella Matos; Nascimento, José Luiz Martins do; Crespo-Lopez, Maria Elena.
Afiliação
  • Arrifano GP; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Augusto-Oliveira M; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Lopes-Araújo A; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Santos-Sacramento L; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Macchi BM; Laboratory of Neurochemistry and Cellular Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Nascimento JLMD; Laboratory of Neurochemistry and Cellular Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Crespo-Lopez ME; Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Int J Environ Res Public Health ; 20(5)2023 02 27.
Article em En | MEDLINE | ID: mdl-36901217
The COVID-19 pandemic affected billions of people worldwide, and exposure to toxic metals has emerged as an important risk factor for COVID-19 severity. Mercury is currently ranked as the third toxic substance of global concern for human health, and its emissions to the atmosphere have increased globally. Both COVID-19 and mercury exposure present a high prevalence in similar regions: East and Southeast Asia, South America and Sub-Saharan Africa. Since both factors represent a multiorgan threat, a possible synergism could be exacerbating health injuries. Here, we discuss key aspects in mercury intoxication and SARS-CoV-2 infection, describing the similarities shared in clinical manifestations (especially neurological and cardiovascular outcomes), molecular mechanisms (with a hypothesis in the renin-angiotensin system) and genetic susceptibility (mainly by apolipoprotein E, paraoxonase 1 and glutathione family genes). Literature gaps on epidemiological data are also highlighted, considering the coincident prevalence. Furthermore, based on the most recent evidence, we justify and propose a case study of the vulnerable populations of the Brazilian Amazon. An understanding of the possible adverse synergism between these two factors is crucial and urgent for developing future strategies for reducing disparities between developed and underdeveloped/developing countries and the proper management of their vulnerable populations, particularly considering the long-term sequelae of COVID-19.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Mercúrio Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Mercúrio Tipo de estudo: Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça