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Prevalence of Antimicrobial Resistance and Clonal Relationship in ESBL/AmpC-Producing Proteus mirabilis Isolated from Meat Products and Community-Acquired Urinary Tract Infection (UTI-CA) in Southern Brazil.
Sanches, Matheus Silva; Silva, Luana Carvalho; Silva, Caroline Rodrigues da; Montini, Victor Hugo; Oliva, Bruno Henrique Dias de; Guidone, Gustavo Henrique Migliorini; Nogueira, Mara Corrêa Lelles; Menck-Costa, Maísa Fabiana; Kobayashi, Renata Katsuko Takayama; Vespero, Eliana Carolina; Rocha, Sergio Paulo Dejato.
Afiliação
  • Sanches MS; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Silva LC; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Silva CRD; Microorganism Research Center, Health Sciences Center, Department of Dermatological, Infectious and Parasitic Diseases, Medical School of São José do Rio Preto, São José do Rio Preto P.O. Box 15.090, Brazil.
  • Montini VH; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Oliva BHD; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Guidone GHM; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Nogueira MCL; Microorganism Research Center, Health Sciences Center, Department of Dermatological, Infectious and Parasitic Diseases, Medical School of São José do Rio Preto, São José do Rio Preto P.O. Box 15.090, Brazil.
  • Menck-Costa MF; Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Kobayashi RKT; Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Vespero EC; Department of Pathology, Health Sciences Center, Clinical and Toxicological Analysis, University Hospital of Londrina, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
  • Rocha SPD; Laboratory of Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
Antibiotics (Basel) ; 12(2)2023 Feb 10.
Article em En | MEDLINE | ID: mdl-36830280
The present study aimed to evaluate the prevalence of antimicrobial resistance and clonal relationships in Proteus mirabilis isolated from chicken meat, beef, pork, and community-acquired urinary tract infections (UTI-CA). Chicken meat isolates showed the highest multidrug resistance (MDR), followed by those from pork and UTI-CA, whereas beef had relatively few MDR strains. All sources had strains that carried blaCTX-M-65, whereas blaCTX-M-2 and blaCMY-2 were only detected in chicken meat and UTI-CA isolates. This indicates that chicken meat should be considered an important risk factor for the spread of P. mirabilis carrying ESBL and AmpC. Furthermore, ESBL/AmpC producing strains were resistant to a greater number of antimicrobials and possessed more resistance genes than non-producing strains. In addition, the antimicrobial resistance genes qnrD, aac(6')-Ib-cr, sul1, sul2, fosA3, cmlA, and floR were also found. Molecular typing showed a genetic similarity between chicken meat and UTI-CA isolates, including some strains with 100% similarity, indicating that chicken can be a source of P. mirabilis causing UTI-CA. It was concluded that meat, especially chicken meat, can be an important source of dissemination of multidrug-resistant P. mirabilis in the community.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Antibiotics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça