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Effect of protection of enoxaparin against experimental ischemia/reperfusion injury in the rat ovary on in vitro fertilization outcomes.
Bostanci, Mehmet Suhha; Budak, Ozcan; Çakiroglu, Hüseyin; Köse, Osman; Durmaz, Özkan; Cokluk, Erdem.
Afiliação
  • Bostanci MS; Sakarya Üniversitesi, Faculty of Medicine, Department of Obstetrics and Gynecology and Artificial Reproductive Techniques - Serdivan, Turkey.
  • Budak O; Sakarya Üniversitesi, Faculty of Medicine, Department of Histology and Embryology and Artificial Reproductive Techniques - Serdivan, Turkey.
  • Çakiroglu H; Sakarya Üniversitesi, Faculty of Medicine, Medical and Experimental Research Center - Serdivan, Turkey.
  • Köse O; Sakarya Üniversitesi, Faculty of Medicine, Department of Urology - Serdivan, Turkey.
  • Durmaz Ö; Sakarya Üniversitesi, Faculty of Medicine, Department of Obstetrics and Gynecology - Serdivan, Turkey.
  • Cokluk E; Sakarya Üniversitesi, Faculty of Medicine, Department of Biochemistry - Serdivan, Turkey.
Rev Assoc Med Bras (1992) ; 69(3): 380-385, 2023.
Article em En | MEDLINE | ID: mdl-36820765
OBJECTIVE: The study aimed to investigate the protection of enoxaparin (E) against experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries on in vitro fertilization outcomes. METHODS: In total, 56 adult female Sprague-Dawley albino rats were randomly assigned to 6 groups of 8 animals each: Sham, Ischemia, I/R, Sham+E, I+E, and I/R+E. Ischemia groups were subjected to bilateral adnexal torsion for 3 h. In contrast, I/R and I/R+E groups received subsequent detorsion for 3 h. Enoxaparin (0.5 mg/kg s.c.) was administered 30 min prior to ischemia (I+platelet-rich plasma) or reperfusion (I/R+I+platelet-rich plasma). Ovaries were stimulated through intraperitoneal injection of 150-300 internal units IU/kg pregnant mare serum gonadotropin. Anti-Müllerian hormone levels were measured before and after surgery in all groups. RESULTS: When the number of metaphase II oocytes was evaluated, statistically significant differences were observed between the I and I+E (p=0.001) and I/R and I/R+E (p=0.000) groups. When both I and I+E groups and I/R and I/R+E groups were compared, it was found that E application increased the number of fertilized oocytes. The number of embryos on the second day was higher in the I/R+E group than that in the I/R group. Statistically significant differences were found in the number of grade 1 embryos between the I/R and I/R+E groups (p=0.003). In comparing anti-Müllerian hormone values within the group, the highest decrease was observed in the I and I/R groups. CONCLUSION: Enoxaparin effectively minimizes ovarian damage and preserves ovarian reserve following ovarian torsion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Ovarianas / Traumatismo por Reperfusão Limite: Animals / Female / Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Ovarianas / Traumatismo por Reperfusão Limite: Animals / Female / Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil