Laboratory predictors for COVID-19 Intensive Care Unit admissions in Trinidad and Tobago.
Dialogues Health
; 1: 100022, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36785629
Understanding symptoms associated with COVID-19 cases requiring intensive care unit(ICU) attention is important in management of the life-threatening cases of the disease. This study aimed to determine laboratory indicators of ICU admission for COVID-19 patients. For this retrospective chart review study, data from 116 patients(ICU, nâ¯=â¯18, Non-ICU, nâ¯=â¯98) with confirmed SARS-CoV-2, managed at two hospitals in Trinidad and Tobago, from March 12th to April 12th 2020, were analyzed. The median age of non-ICU patients was 59.0(IQRâ¯=â¯23.5) years; ICU patients had a median age of 62.5(IRâ¯=â¯17.5). From univariate analysis, laboratory indicators significantly associated with ICU admission included WBC(Pâ¯=â¯0.037), lymphocyte(Pâ¯=â¯0.016), LDH(Pâ¯=â¯0.002), AST(Pâ¯=â¯0.005) and CRP(Pâ¯=â¯0.0001). However, multivariate analysis including WBC, neutrophil, lymphocyte, PLT, AST, LDH, ALT and CRP indicated that only AST was associated with high odds of ICU admission(OR 0.002, 95% CI 0.000-0.004, Pâ¯=â¯0.017). Statistically significant AUC were obtained for neutrophil(AUCâ¯=â¯0.704, Pâ¯=â¯0.007), CRP (AUCâ¯=â¯0.81, pâ¯=â¯0.00) and LDH(AUCâ¯=â¯0.766, Pâ¯=â¯0.00) and AST (AUCâ¯=â¯0.729, Pâ¯=â¯0.003). The findings indicate that neutrophils, AST and LDH's ROC curves are good tests, CRP curve is a very good test, but lymphocyte curve is a poor test, in determining COVID-19 patients for ICU admission. Neutrophil, AST, LDH and CRP are suitable predictors of COVID-19 patients that should receive intensive unit care. The study provides significant insights into laboratory parameters that can be used to predict COVID-19 severity and important considerations for healthcare providers in making evidence-based decisions regarding COVID-19 patient management, especially in the context of limited ICU facilities. This study was not funded.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
País/Região como assunto:
Caribe ingles
/
Trinidad y tobago
Idioma:
En
Revista:
Dialogues Health
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Trinidad e Tobago
País de publicação:
Estados Unidos