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Epidermolysis bullosa in oral health: clinical manifestations and salivary alterations.
de Azevedo, Brenda Lamônica Rodrigues; Roni, Gabriel Marim; Dettogni, Raquel Spinassé; Torrelio, Rosalie Matuk Fuentes; Leal, Lucas Fernandes; da Gama-de-Souza, Letícia Nogueira.
Afiliação
  • de Azevedo BLR; Graduate Program in Dental Science, Health Science Center, Federal University of Espírito Santo, Vitória, ES, Brazil.
  • Roni GM; Medical School, Morphology Department, Health Science Center, Federal University of Espírito Santo, Vitória, Brazil.
  • Dettogni RS; Morphology Department, Health Science Center, Federal University of Espírito Santo, Vitória, ES, Brazil.
  • Torrelio RMF; Plastic Surgery, Hospital Infantil Nossa Senhora da Glória, Debra, Vitória, ES, Brazil.
  • Leal LF; Faculdades Integradas Espírito Santenses (FAESA), Vitória, ES, Brazil.
  • da Gama-de-Souza LN; Graduate Program in Dental Science, Morphology Department, Health Science Center, Federal University of Espírito Santo, Avenue Marechal Campos, 1468, Maruípe, 29.040-090, Vitória, ES, Brazil. leticia.souza@ufes.br.
Clin Oral Investig ; 27(6): 3117-3124, 2023 Jun.
Article em En | MEDLINE | ID: mdl-36781477
Epidermolysis bullosa (EB) is an inherited disease characterized by the fragility of the skin and mucous membranes. All types/subtypes of EB can lead to alterations in the mouth and glands. OBJECTIVE: To evaluate clinical manifestations of EB on the oral mucosa and alterations in salivary flow. MATERIALS AND METHODS: Sociodemographic and clinical data were obtained from EB individuals. The salivary flow analysis was performed in EB and in non-EB patients. Fischer's exact test was applied to the qualitative variables, and the Mann-Whitney test was applied to the quantitative data. RESULTS: A total of 11 cases of EB were evaluated, and 3 types of EB were diagnosed (recessive dystrophic-RDEB; junctional-JEB; and simplex-EBS). Only individuals with RDEB or JEB showed the oral manifestation of the disease. The most affected sites were the lips (54%), hard palate (36%), and oral mucosa (27%). Ulcer and ankyloglossia were diagnosed in all RDEB cases. Regarding salivary flow, an intragroup comparison revealed an increase in stimulated versus unstimulated collection in the control sample (p = 0.0064). The EB group showed no difference (p = 0.6086). We also observed no differences in salivary volume between the control and EB groups (p = 0.7117 and p = 0.5557, unstimulated and stimulated flows, respectively). CONCLUSIONS: No oral manifestations were observed in EBS subjects. It is unclear whether individuals with EB are predisposed to manifest hyposalivation. CLINICAL RELEVANCE: Severe cases of EB show broad alterations in the oral mucosa, whereas the saliva needs to be better evaluated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde Bucal / Epidermólise Bolhosa Tipo de estudo: Qualitative_research Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saúde Bucal / Epidermólise Bolhosa Tipo de estudo: Qualitative_research Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha