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A comprehensive overview of genotoxicity and mutagenicity associated with outdoor air pollution exposure in Brazil.
Vargas, Vera Maria Ferrão; da Silva Júnior, Flavio Manoel Rodrigues; Silva Pereira, Tatiana da; Silva, Cristiane Silva da; Coronas, Mariana Vieira.
Afiliação
  • Vargas VMF; Programa de Pós-graduação em Ecologia, Universidade Federal do Rio Grande do Sul (UFRGS). Av. Bento Gonçalves, Porto Alegre, RS, Brazil.
  • da Silva Júnior FMR; Programa de Pós-graduaç'ão em Ci"ências da Saúde, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, Brazil.
  • Silva Pereira TD; Laboratório de Aquicultura de Peixes Ornamentais do Xingu, Universidade Federal do Pará (UFPA), Altamira, PA, Brazil.
  • Silva CSD; Programa de Pós-graduação em Ecologia, Universidade Federal do Rio Grande do Sul (UFRGS). Av. Bento Gonçalves, Porto Alegre, RS, Brazil.
  • Coronas MV; Instituto Federal de Educação, Ciênciae Tecnologia do Rio Grande do Sul (IFRS), Canoas, RS, Brazil.
J Toxicol Environ Health B Crit Rev ; 26(3): 172-199, 2023 04 03.
Article em En | MEDLINE | ID: mdl-36775848
This review examined the mutagenicity and genotoxicity associated with exposure to outdoor air pollutants in Brazil. A search was performed on the Web of Science database using a combination of keywords that resulted in 134 articles. After applying exclusion criteria, a total of 75 articles were obtained. The articles were classified into three categories: (1) studies with plants and animals, (2) in vitro studies, and (3) human biomonitoring. The investigations were conducted in 11 of 27 Brazilian states with the highest prevalence in the southeast and south regions. Only 5 investigations focused on the effects of burning biomass on the quality of outdoor air. Plants, especially Tradescantia pallida, were the main air pollution biomonitoring tool. When available, a significant association between levels of air pollutants and genetic damage was described. Among the in vitro studies, Salmonella/microsome is the most used test to evaluate mutagenesis of outdoor air in Brazil (n = 26). Human biomonitoring studies were the least frequent category (n = 18). Most of the investigations utilized micronucleus bioassay, in oral mucosa cells (n = 15) and lymphocytes (n = 5), and the comet assay (n = 6). The analysis in this study points to the existence of gaps in genotoxicity studies and our findings indicate that future studies need to address the variety of potential sources of pollution existing in Brazil. In addition to extent of the impacts, consideration should be given to the enormous Brazilian biodiversity, as well as the determination of the role of socioeconomic inequality of the population in the observed outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar Tipo de estudo: Risk_factors_studies Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Toxicol Environ Health B Crit Rev Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar Tipo de estudo: Risk_factors_studies Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Toxicol Environ Health B Crit Rev Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido