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Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients.
Rodríguez, Ivon Johanna; Bernal-Estévez, David A; Llano-León, Manuela; Bonilla, Carlos Eduardo; Parra-López, Carlos Alberto.
Afiliação
  • Rodríguez IJ; Departamento de Microbiología, Laboratorio de Inmunología y Medicina Traslacional, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Bernal-Estévez DA; Departamento de Movimiento Corporal Humano, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Llano-León M; Immunology and Clinical Oncology Research Group (GIIOC), Fundación Salud de los Andes, Bogotá, Colombia.
  • Bonilla CE; Departamento de Microbiología, Laboratorio de Inmunología y Medicina Traslacional, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Parra-López CA; Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.
PLoS One ; 18(2): e0280851, 2023.
Article em En | MEDLINE | ID: mdl-36763585
Breast cancer is the leading cause of cancer deaths in women worldwide. It has been observed that the incidence of breast cancer increases linearly with age after 45, which suggest a link between cancer, aging, and senescence. A growing body of evidence indicates that the immunosuppressive tumor network in breast cancer patients can lead to T-cell exhaustion and senescence. Cytotoxic chemotherapy is a common treatment for many cancers, and it is hypothesized that its efficacy may be related to immune activation. However, the effects of neoadjuvant chemotherapy on T-cell dysfunction in breast cancer patients are not fully understood. This study aimed to evaluate the impact of neoadjuvant chemotherapy on the expression of exhaustion and senescence markers in T cells in women with breast cancer. Our results showed that T cells from breast cancer patients have a reduced ability to respond to stimulation in-vitro and an increased expression of senescence and exhaustion-associated markers, such as TIM-3, LAG3, and CD57. Furthermore, we found that neoadjuvant chemotherapy has an immunomodulatory effect and reduces the expression of exhaustion markers. Our observations of the immune phenotype of T cells during neoadjuvant chemotherapy treatment highlight its ability to stimulate the immune system against cancer. Therefore, monitoring the response of T cells during chemotherapy may enable early prediction of clinical response.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Neoplasias Limite: Female / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Neoplasias Limite: Female / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos