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Impacts of Curcumin Treatment on Experimental Sepsis: A Systematic Review.
Vieira, Barbara Martins; Caetano, Marcos Antonio Ferreira; de Carvalho, Mara Taís; Dos Santos Arruda, Felipe; Tomé, Fernanda Dias; de Oliveira, Jordana Fernandes; Soave, Danilo Figueiredo; Pereira, Jonathas Xavier; Celes, Mara Rubia Nunes.
Afiliação
  • Vieira BM; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
  • Caetano MAF; Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
  • de Carvalho MT; Department of Animal Science, School of Veterinary and Animal Science, Federal University of Goiás, Goiania, Goias, Brazil.
  • Dos Santos Arruda F; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
  • Tomé FD; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
  • de Oliveira JF; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
  • Soave DF; Department of Morphofunctional, Faculty of Medicine of Goianesia, University of Rio Verde, Goianesia, Goias, Brazil.
  • Pereira JX; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
  • Celes MRN; Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
Oxid Med Cell Longev ; 2023: 2252213, 2023.
Article em En | MEDLINE | ID: mdl-36756300
Background and Aims: Sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host immune response to an infection. Curcumin is a yellow polyphenol derived from the rhizome of Curcuma longa with anti-inflammatory and antioxidant properties scientifically proven, a condition that allowed its use as a tool in the treatment of sepsis. Thus, the purpose of this article was to systematically review the evidence on the impact of curcumin's anti-inflammatory effect on experimental sepsis. Methods: For this, the PubMed, MEDLINE, EMBASE, Scopus, Web of Science, and LILACS databases were used, and the research was not limited to a specific publication period. Only original articles in English using in vivo experimental models (rats or mice) of sepsis induction performed by administration of lipopolysaccharide (LPS) or cecal ligation and perforation surgery (CLP) were included in the study. Studies using curcumin in dry extract or with a high degree of purity were included. At initial screening, 546 articles were selected, and of these, 223 were eligible for primary evaluation. Finally, 12 articles with full text met all inclusion criteria. Our results showed that curcumin may inhibit sepsis-induced complications such as brain, heart, liver, lungs, and kidney damage. Curcumin can inhibit inflammatory factors, prevent oxidative stress, and regulate immune responses in sepsis. Additionally, curcumin increased significantly the survival rates after experimental sepsis in several studies. The modulation of the immune response and mortality by curcumin reinforces its protective effect on sepsis and indicates a potential therapeutic tool for the treatment of sepsis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Curcumina Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Curcumina Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos