Your browser doesn't support javascript.
loading
Osteogenic sarcomas of the hands: A case series with emphasis in its peculiarities and literature review.
de la Guardia, Valli; O'Meally, Ahmed Atherley; Gambarotti, Marco; Spinnato, Paolo; Frisoni, Tommaso; Cocchi, Stefania; Magagnoli, Giovanna; Ibrahim, Toni; Benini, Stefania; Pacheco, Marina; Righi, Alberto.
Afiliação
  • de la Guardia V; Department of Pathology, Complejo Hospitalario Metropolitano CSS, Panama, Panama.
  • O'Meally AA; Department of Orthopaedic Surgery, Complejo Hospitalario Metropolitano CSS, Panama, Panama.
  • Gambarotti M; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Spinnato P; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Frisoni T; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Cocchi S; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Magagnoli G; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Ibrahim T; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Benini S; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Pacheco M; Department of Pathology, Complejo Hospitalario Metropolitano CSS, Panama, Panama.
  • Righi A; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Electronic address: alberto.righi@ior.it.
Pathol Res Pract ; 242: 154326, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36716613
AIM: To present our experience on osteosarcomas of the hands and review the existing literature pertaining osteosarcomas in this extremely rare location. METHODS: and results: Seven cases of osteosarcomas of the hands were reviewed, and a literature search of all primary osteosarcomas of the hands was performed. All tumors occurred in adults (mean age, 41 years) and were located mainly around the metacarpophalangeal joints. All patients presented with localized long-lasting pain as main symptom. The mean size at diagnosis was 33 mm. Three tumors were low-grade central osteosarcomas, 1 low-grade central chondroblastoma-like osteosarcoma and 3 high-grade osteosarcomas. All tumors were positive for mouse double-minute 2 homolog (MDM2) immunohistochemistry. Three cases yielded results with fluorescence in-situ amplification for MDM2 (12q15)/CEP12. At last follow-up, one patient with a high-grade osteosarcoma was dead of disease. The literature review revealed similar demographic and site distribution of osteosarcomas within the hands than our series and an unusually high proportion of low-grade central and parosteal osteosarcomas when compared to the proportion of these infrequent neoplasms in the whole skeleton. CONCLUSIONS: osteosarcomas of hands present in older individuals compared to the population affected by conventional osteosarcomas of all sites. Importantly from a diagnostic, therapeutic and prognostic points of view, around 40% of osteosarcomas of the hands are low-grade osteosarcomas of the central or parosteal types.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pathol Res Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Panamá País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pathol Res Pract Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Panamá País de publicação: Alemanha