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Dengue fever ophthalmic manifestations: A review and update.
Lucena-Neto, Francisco Dias; Falcão, Luiz Fabio Magno; Moraes, Evelly Christinne da Silva; David, Joacy Pedro Franco; Vieira-Junior, Adolfo de Souza; Silva, Camilla Costa; de Sousa, Jorge Rodrigues; Duarte, Maria Irma Seixas; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões.
Afiliação
  • Lucena-Neto FD; State University of Pará, Belém, Pará, Brazil.
  • Falcão LFM; State University of Pará, Belém, Pará, Brazil.
  • Moraes ECDS; Federal University of Pará, Belém, Pará, Brazil.
  • David JPF; Federal University of Pará, Belém, Pará, Brazil.
  • Vieira-Junior AS; State University of Pará, Belém, Pará, Brazil.
  • Silva CC; State University of Pará, Belém, Pará, Brazil.
  • de Sousa JR; State University of Pará, Belém, Pará, Brazil.
  • Duarte MIS; School of Medicine, São Paulo University, São Paulo, São Paulo, Brazil.
  • Vasconcelos PFDC; State University of Pará, Belém, Pará, Brazil.
  • Quaresma JAS; State University of Pará, Belém, Pará, Brazil.
Rev Med Virol ; 33(2): e2422, 2023 03.
Article em En | MEDLINE | ID: mdl-36658757
Dengue fever, the most common arbovirus disease, affects an estimated 390 million people annually. Dengue virus (DENV) is an RNA virus of the Flaviviridae family with four different serotypes. Dengue haemorrhagic fever is the deadliest form of dengue infection and is characterised by thrombocytopaenia, hypotension, and the possibility of multi-system organ failure. The mechanism hypothesised for DENV viral replication is intrinsic antibody-dependent enhancement, which refers to Fcγ receptor-mediated viral amplification. This hypothesis suggests that the internalisation of DENV through the Fcγ receptor inhibits antiviral genes by suppressing type-1 interferon-mediated antiviral responses. DENV NS1 antibodies can promote the release of various inflammatory mediators in the nuclear transcription factor pathway (NF-κB-dependent), including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, and IL-8. As a result, MCP-1 increases ICAM-1 expression and facilitates leukocyte transmigration. In addition, anti-DENV NS1 antibodies induce endothelial cell apoptosis via a nitric oxide-regulated pathway. A chain reaction involving pre-existing DENV heterotypic antibodies and innate immune cells causes dysfunction in complement system activity and contributes to the action of autoantibodies and anti-endothelial cells, resulting in endothelial cell dysfunction, blood-retinal barrier breakdown, haemorrhage, and plasma leakage. A spectrum of ocular diseases associated with DENV infection, ranging from haemorrhagic to inflammatory manifestations, has been reported in the literature. Although rare, ophthalmic manifestations can occur in both the anterior and posterior segments and are usually associated with thrombocytopenia. The most common ocular complication is haemorrhage. However, ophthalmic complications, such as anterior uveitis and vasculitis, suggest an immune-mediated pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombocitopenia / Dengue / Vírus da Dengue Limite: Humans Idioma: En Revista: Rev Med Virol Assunto da revista: VIROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombocitopenia / Dengue / Vírus da Dengue Limite: Humans Idioma: En Revista: Rev Med Virol Assunto da revista: VIROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido