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Laryngeal Mucous Membrane Pemphigoid as an Immune-related Adverse Effect of Pembrolizumab Treatment.
Lagos-Villaseca, Antonia; Koshkin, Vadim S; Kinet, Maxime J; Rosen, Clark A.
Afiliação
  • Lagos-Villaseca A; UCSF Voice & Swallowing Center, Division of Laryngology, Department of Otolaryngology-Head & Neck Surgery, University of California San Francisco, San Francisco, California; Department of Otolaryngology, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Koshkin VS; Division of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
  • Kinet MJ; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California.
  • Rosen CA; UCSF Voice & Swallowing Center, Division of Laryngology, Department of Otolaryngology-Head & Neck Surgery, University of California San Francisco, San Francisco, California. Electronic address: clark.rosen@ucsf.edu.
J Voice ; 2023 Jan 18.
Article em En | MEDLINE | ID: mdl-36658034
Pembrolizumab is an immune checkpoint inhibitor (ICI) approved for multiple indications in a variety of malignancies. Although generally well tolerated, the potential for significant adverse effects, specifically immune related adverse effects (irAEs) needs to be taken into consideration. Several cases of bullous pemphigoid have been reported as a cutaneous adverse effect of ICIs since 2015, and there are recent reports of mucous membrane pemphigoid (MMP). We present the case of an 84-year-old male with metastatic urothelial carcinoma on treatment with pembrolizumab, who developed laryngeal mucous membrane pemphigoid as an irAE. The diagnosis was based on patient's clinical history and serologic testing, and supported by symptomatic improvement after ICI discontinuation and immunosuppression. Pembrolizumab-induced MMP is a newly described and infrequent irAE, requiring early suspicion and close monitoring for its diagnosis and management.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Voice Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Voice Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos