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WHICH LESIONS ARE AT HIGHER RISK OF DEVELOPING COLORECTAL CARCINOMAS: SUPERFICIALLY ELEVATED SERRATED LESIONS OR DEPRESSED LESIONS?
Parada, Artur Adolfo; Venco, Filadelfio Euclydes; Varca-Neto, Miguel Reynaldo; El Ibrahim, Roberto; Poletti, Paula Bechara; Brito, Helcio Pedrosa; Sare, Heloisa de Fátima; Malafaia, Osvaldo.
Afiliação
  • Parada AA; Faculdade Evangélica Mackenzie do Paraná, Postgraduate Program in Principles of Surgery - Curitiba (PR), Brazil.
  • Venco FE; Nove de Julho Hospital, Center for Endoscopic Diagnosis and Therapeutics of São Paulo - São Paulo (SP), Brazil.
  • Varca-Neto MR; Nove de Julho Hospital, Center for Endoscopic Diagnosis and Therapeutics of São Paulo - São Paulo (SP), Brazil.
  • El Ibrahim R; Nove de Julho Hospital, Center for Endoscopic Diagnosis and Therapeutics of São Paulo - São Paulo (SP), Brazil.
  • Poletti PB; Nove de Julho Hospital, Center for Endoscopic Diagnosis and Therapeutics of São Paulo - São Paulo (SP), Brazil.
  • Brito HP; Nove de Julho Hospital, Center for Endoscopic Diagnosis and Therapeutics of São Paulo - São Paulo (SP), Brazil.
  • Sare HF; Faculdade Evangélica Mackenzie do Paraná, Postgraduate Program in Principles of Surgery - Curitiba (PR), Brazil.
  • Malafaia O; Faculdade Evangélica Mackenzie do Paraná, Postgraduate Program in Principles of Surgery - Curitiba (PR), Brazil.
Arq Bras Cir Dig ; 35: e1716, 2023.
Article em En | MEDLINE | ID: mdl-36629693
BACKGROUND: There are lesions that are still being missed in colonoscopy. Many of those could be superficially elevated serrated lesions or depressed ones. AIMS: The aim of this study was to compare the histopathological characteristics of these lesions and their risks for submucosal carcinoma. METHODS: This is a retrospective, cross-sectional, and observational study comparing 217 superficially elevated serrated lesions larger than 5 mm resected by colonoscopies (G1) with 558 depressed lesions (G2). RESULTS: In G1, 217 lesions were found in 12,653 (1.7%) colonoscopies; in G2, 558 lesions were found in 36,174 (1.5%) colonoscopies. In G1, 63.4% were women and in G2, there was no gender predominance. The average size of G1 was 16.2 mm and G2 was 9.2 mm (p<0.001). G1 predominated on the proximal colon and G2 on the distal and rectum (p<0.001). In G1, there were 214 (98.6%) low-grade intramucosal neoplasia and 3 (1.4%) high-grade intramucosal neoplasia. Excluding 126 hyperplastic polyps and considering 91 sessile serrated adenomas in G1, we observed 88 (96.7%) low-grade intramucosal neoplasia and 3 (3.3%) high-grade intramucosal neoplasia; in G2, we observed 417 (74.7%) low-grade intramucosal neoplasia, 113 (20.3%) high-grade intramucosal neoplasia, and 28 (5.0%) submucosal adenocarcinomas (p<0.001). CONCLUSION: Depressed lesions significantly had more high-grade intramucosal neoplasia and more invasive carcinomas in the submucosal layer than superficially elevated serrated lesions and more than superficially elevated sessile serrated adenomas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias Colorretais / Adenoma / Pólipos do Colo Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias Colorretais / Adenoma / Pólipos do Colo Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil