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Long-Term Changes in Bone Density and Bone Metabolism After Gastric Bypass Surgery: a Retrospective Cohort Study.
Sperb, Luiza Ferreira; Leotti, Vanessa Bielefeldt; Silveiro, Sandra Pinho; de Azevedo, Mirela Jobim; Viana, Luciana Verçoza.
Afiliação
  • Sperb LF; Post-Graduate Program in Medical Sciences - Endocrinology (PPG ENDO), Universidade Federal do Rio Grande do Sul, (UFRGS), Porto Alegre, Brazil. luizafsperb@gmail.com.
  • Leotti VB; Statistics Department, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
  • Silveiro SP; Department of Internal Medicine - Endocrinology Division, HCPA and Faculty of Medical Sciences (FAMED/UFRGS), Porto Alegre, Brazil.
  • de Azevedo MJ; Department of Internal Medicine - Endocrinology Division, HCPA and Faculty of Medical Sciences (FAMED/UFRGS), Porto Alegre, Brazil.
  • Viana LV; Department of Internal Medicine - Endocrinology Division, HCPA and Faculty of Medical Sciences (FAMED/UFRGS), Porto Alegre, Brazil.
Obes Surg ; 33(3): 911-919, 2023 03.
Article em En | MEDLINE | ID: mdl-36609743
PURPOSE: Patients with severe obesity submitted to Roux-en-Y gastric bypass (RYGB) are at risk of developing long-term hypovitaminosis D and secondary hyperparathyroidism (SHPT) as well as osteometabolic disease. This study aimed to evaluate calcium-vitamin D-PTH axis and bone mineral density (BMD) changes from post-RYGB patients who were followed-up until a median of 5 years. MATERIALS AND METHODS: Vitamin D deficiency was defined as 25-hydroxyvitamin D <20 ng/mL and SHPT as PTH >68 pg/mL, in patients with normal serum creatinine and calcium. BMD was estimated by dual-energy X-ray absorptiometry (DXA, g/cm2). RESULTS: We included 127 post-RYGB patients (51±10.6 years, 87.4% self-declared White, 91.3% female, 52.8% postmenopausal). Vitamin D deficiency prevalence was the highest (41.5%) in the second year and the lowest (21.2%) in the third year (p<0.05). SHPT prevalence was 65.4% in the second year and increased to 83.7% in the sixth year (p<0.05). Patients with low BMD in lumbar, femoral neck, and total proximal femur were older and presented menopausal status more frequently than normal BMD group (p<0.05). Older age was a risk marker for altered BMD in femoral neck (OR=1.185; 95% CI 1.118-1.256) and in total proximal femur (OR=1.158; 95% CI 1.066-1.258), both after adjusting for follow-up and excess weight loss. CONCLUSION: After 5 years, most bariatric patients presented calcium-vitamin D-PTH axis disruption, in which SHPT was more frequent than hypovitaminosis D. Older patients and menopausal women presented higher rates of low BMD, and older age was a risk marker, especially for low BMD in femoral sites.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina D / Doenças Ósseas Metabólicas / Obesidade Mórbida / Derivação Gástrica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina D / Doenças Ósseas Metabólicas / Obesidade Mórbida / Derivação Gástrica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos