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Biphasic dissolution combined with modified cylinder method-A new promising method for dissolution test in drug-loaded nanoemulsions.
Yukuyama, Megumi Nishitani; Zuo, Jieyu; Park, Chulhun; Yousef, Malaz; Henostroza, Mirla Anali Bazán; de Araujo, Gabriel Lima Barros; Bou-Chacra, Nádia Araci; Löbenberg, Raimar.
Afiliação
  • Yukuyama MN; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 8613 - 114 St NW, T6G 2H7 Edmonton, AB, Canada; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av, 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
  • Zuo J; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 8613 - 114 St NW, T6G 2H7 Edmonton, AB, Canada.
  • Park C; College of Pharmacy, Jeju National University, Jeju 63243, Republic of Korea.
  • Yousef M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 8613 - 114 St NW, T6G 2H7 Edmonton, AB, Canada.
  • Henostroza MAB; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av, 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
  • de Araujo GLB; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av, 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil. Electronic address: gabriel.araujo@usp.br.
  • Bou-Chacra NA; Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes Av, 580, Cidade Universitária, 05508-000 São Paulo, SP, Brazil. Electronic address: chacra@usp.br.
  • Löbenberg R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 8613 - 114 St NW, T6G 2H7 Edmonton, AB, Canada.
Int J Pharm ; 632: 122554, 2023 Feb 05.
Article em En | MEDLINE | ID: mdl-36586637
Dissolution testing is important in assessing the in vitro drug release performance for oral administration dosage forms. However, currently, a simple and efficient in vitro test to investigate critical factors that may impact the drug release and bioavailability at the development stage of a drug-loaded nanoemulsion (NE) is lacking. Thus, in this study, we developed a new combined biphasic and modified cylinder (BP + MC) method to evaluate the dissolution profile of NEs. Flubendazole (FLZ), a Biopharmaceutical Classification System (BCS) Class II drug, offers a new prospective for drug repositioning for treating lung cancer and cryptococcal meningitis. We compared the drug release profiles of three different FLZ formulations (micronized as a suspension, loaded in NE, and solubilized in oil) by using three different methods (dialysis bag, modified cylinder method, and a new BP + MC method). The results showed potential higher drug release of FLZ from the suspension compared to FLZ-loaded NE at pH 1.2, and higher drug release from FLZ-loaded NE compared to other forms in octanol phase. These results correlate well with the in vivo test performed in mice carried out in our previous works. Furthermore, the partition mechanism of the drug released from the NE is discussed in-depth in this article, as well as the advantage of drug-loaded NEs over other preparations in creating supersaturable conditions. Based on the results, we provide new insights into how dissolution methods for a poorly water-solubility drug can be designed. Therefore, we present this new combined BP + MC method as a potential new discriminative dissolution test for future studies when developing drug-loaded NE and comparing with other dosage forms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solubilidade Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solubilidade Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda