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Adenosine receptors participate in anabolic-androgenic steroid-induced changes on risk assessment/anxiety-like behaviors in male and female rats.
Penna, D B S; Raony, Ícaro; Jardim-Messeder, Débora; Dos Santos-Rodrigues, Alexandre; Pandolfo, Pablo.
Afiliação
  • Penna DBS; Program of Neurosciences and Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil; Program of Physiology and Pharmacology, Biomedical Institute, Federal Fluminense University, Niterói, Brazil.
  • Raony Í; Program of Neurosciences and Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.
  • Jardim-Messeder D; Program of Neurosciences and Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.
  • Dos Santos-Rodrigues A; Program of Neurosciences and Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.
  • Pandolfo P; Program of Neurosciences and Department of Neurobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil; Program of Physiology and Pharmacology, Biomedical Institute, Federal Fluminense University, Niterói, Brazil. Electronic address: pablopandolfo@gmail.com.
Physiol Behav ; 261: 114071, 2023 03 15.
Article em En | MEDLINE | ID: mdl-36584765
Anabolic-androgenic steroids (AAS) and caffeine can induce several behavioral alterations in humans and rodents. Administration of nandrolone decanoate is known to affect defensive responses to aversive stimuli, generally decreasing inhibitory control and increasing aggressivity but whether caffeine intake influences behavioral changes induced by AAS is unknown. The present study aimed to investigate behavioral effects of caffeine (a non-selective antagonist of adenosine receptors) alone or combined with nandrolone decanoate (one of the most commonly AAS abused) in female and male Lister Hooded rats. Our results indicated that chronic administration of nandrolone decanoate (10 mg/kg, i.m., once a week for 8 weeks) decreased risk assessment/anxiety-like behaviors (in the elevated plus maze test), regardless of sex. These effects were prevented by combined caffeine intake (0.1 g/L, p.o., ad libitum). Overall, the present study heralds a key role for caffeine intake in the modulation of nandrolone decanoate-induced behavioral changes in rats, suggesting adenosine receptors as candidate targets to manage impact of AAS on brain function and behavior.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Purinérgicos P1 / Decanoato de Nandrolona / Esteróides Androgênicos Anabolizantes / Anabolizantes Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Purinérgicos P1 / Decanoato de Nandrolona / Esteróides Androgênicos Anabolizantes / Anabolizantes Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos