Visible-Light Mediated Carbamoylation of Nitrones under a Continuous Flow Regime.

Oliveira, Pedro H R; Tordato, Éverton A; Vélez, Jeimy A C; Carneiro, Pablo S; Paixão, Márcio W

Oliveira, Pedro H R; Tordato, Éverton A; Vélez, Jeimy A C; Carneiro, Pablo S; Paixão, Márcio W.

Afiliação

Oliveira PHR; Centre of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Tordato ÉA; Centre of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Vélez JAC; Centre of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Carneiro PS; Centre of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Paixão MW; Centre of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, São Carlos, São Paulo 13565-905, Brazil.

J Org Chem ; 88(10): 6407-6419, 2023 May 19.

Article em En | MEDLINE | ID: mdl-36576774

RESUMO

Herein, we report a rapid and scalable continuous-flow photocatalytic approach for the carbamoylation of nitrones. This protocol makes use of readily available 4-amido-1,4 dihydropyridines as carbamoyl radical precursors. The scope of this transformation exhibits high compatibility with complex structures containing amino acids, peptides, and glycosides. Importantly, the developed method allows a photocatalytic synthetic strategy in combination with flow conditions, maximizing the potential and efficiency for the synthesis of valuable α-(N-hydroxy)amino amides.

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google