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Isolation and Characterization of Flavonoid Naringenin and Evaluation of Cytotoxic and Biological Efficacy of Water Lilly (Nymphaea mexicana Zucc.).
Din, Shajrath; Hamid, Saima; Yaseen, Aadil; Yatoo, Ali Mohd; Ali, Shafat; Shamim, Kashif; Mahdi, Wael A; Alshehri, Sultan; Rehman, Muneeb U; Shah, Wajaht A.
Afiliação
  • Din S; Department of Chemistry, University of Kashmir, Srinagar 190006, India.
  • Hamid S; Centre of Research for Development, University of Kashmir, Srinagar 190006, India.
  • Yaseen A; Department of Chemistry, University of Kashmir, Srinagar 190006, India.
  • Yatoo AM; Centre of Research for Development, University of Kashmir, Srinagar 190006, India.
  • Ali S; Centre of Research for Development, University of Kashmir, Srinagar 190006, India.
  • Shamim K; National Centre for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA.
  • Mahdi WA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Alshehri S; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Rehman MU; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Shah WA; Department of Chemistry, University of Kashmir, Srinagar 190006, India.
Plants (Basel) ; 11(24)2022 Dec 19.
Article em En | MEDLINE | ID: mdl-36559700
Despite its limited exploration, Nymphaea mexicana Zucc. can be beneficial if pharmacology, isolation, and biological evaluation are given attention. It is an aquatic species that belongs to the family Nymphaeaceae. The thrust area of the work was the extraction, isolation, and biological evaluation of different extracts of the N. mexicana Zucc. plant. The primary goal of this research was to assess the antimicrobial, antioxidant, and anticancer activities of the extracts and to isolate the target naringenin compound. Comparative FT IR analysis of different extracts of this plant revealed the presence of functional groups of plant secondary metabolites, including polyphenols, flavonoids, terpenoids, esters, amines, glycosides, alkanes, alkaloids, fatty acids, and alcohols. Moderate free radical scavenging potential has been achieved for the various extracts via reducing power and DPPH assays. While cytotoxic activity was evaluated by colorimetric and lactate dehydrogenase cell viability tests on potent cancer cell lines. Lung adenocarcinoma epithelial cells (A-549), and breast cells (MC-7) were treated with MeOH extract. The antimicrobial activity against bacterial strains was evaluated using Gram-positive and -negative cultures, where maximum and minimum inhibition zones were recorded for different strains, including 1.6-25.6 µg/mL for Streptococcus aureus, using the agar well diffusion method. In addition, the anti-inflammatory activity of different extracts of N. mexicana Zucc. was evaluated in a nitrite radical scavenging assay with high concentrations of secondary metabolites, which are important against human pathogens and other diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Plants (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Plants (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia País de publicação: Suíça