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Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study.
Landeros, Natalia; Duk, Soledad; Márquez, Carolina; Inzunza, Bárbara; Acuña-Rodríguez, Ian S; Zúñiga-Venegas, Liliana A.
Afiliação
  • Landeros N; Centro Oncológico, Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile.
  • Duk S; Laboratorio de Investigaciones Biomédicas (LIB), Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile.
  • Márquez C; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
  • Inzunza B; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
  • Acuña-Rodríguez IS; Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile.
  • Zúñiga-Venegas LA; Instituto de Investigaciones Interdisciplinarias (I3), Universidad de Talca, Talca 3465548, Chile.
Int J Environ Res Public Health ; 19(24)2022 12 10.
Article em En | MEDLINE | ID: mdl-36554491
Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management (n = 30) and an urban unexposed group (n = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: ß = 13.27; 95% CI low = 11.08, CI high = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI low = 2.60, CI high = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Exposição Ocupacional Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Chile Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Exposição Ocupacional Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Chile Idioma: En Revista: Int J Environ Res Public Health Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Chile País de publicação: Suíça