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Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation.
D'Abadia, Patrícia Lima; Lemes, Susy Ricardo; Melo-Reis, Paulo Roberto de; Lino Júnior, Ruy de Souza; Gonçalves, Pablo José; Reis, Diego Dos Santos; Caixeta, Graziele Alícia Batista; Amaral, Vanessa Cristine Santana; Almeida, Luciane Madureira.
Afiliação
  • D'Abadia PL; Graduate student. Universidade Estadual de Goiás - Programa Recursos Naturais do Cerrado - Biotechnology Laboratory - Anápolis (GO), Brazil.
  • Lemes SR; PhD, Assistant professor. Centro Universitário Goyazes - Department of Agricultural Science - Trindade (GO), Brazil.
  • Melo-Reis PR; PhD, Assistant professor. Pontifícia Universidade Católica de Goiás - Biomedicine Department - Laboratory of Experimental and Biotechnological Studies - Goiânia (GO), Brazil.
  • Lino Júnior RS; PhD, Associate professor. Universidade Federal de Goiás - Experimental Pathology Laboratory - Institute of Tropical Pathology and Public Health - Goiânia (GO), Brazil.
  • Gonçalves PJ; PhD, Associate professor. Universidade Federal de Goiás - Institute of Physics - Goiânia (GO), Brazil.
  • Reis DDS; Graduate student. Universidade Estadual de Goiás - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.
  • Caixeta GAB; Graduate student. Universidade Estadual de Goiás - Sciences Applied to Health Products - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.
  • Amaral VCS; PhD, Full professor. Universidade Estadual de Goiás - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.
  • Almeida LM; PhD, Full professor. Universidade Estadual de Goiás - Biotechnology Laboratory - Anápolis (GO), Brazil.
Acta Cir Bras ; 37(10): e371001, 2022.
Article em En | MEDLINE | ID: mdl-36542039
PURPOSE: Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds. METHODS: One hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen. RESULTS: The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues. CONCLUSIONS: H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apocynaceae / Látex Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apocynaceae / Látex Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil