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Fungicidal and antibiofilm activities of gold nanoparticles on Candida tropicalis.
da Silva, María Angel; García-Martínez, Joaquín Calizto; Páez, Paulina Laura; Paraje, María Gabriela.
Afiliação
  • da Silva MA; Instituto Multidisciplinario de Biología Vegetal (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, X5000JJC, Argentina.
  • García-Martínez JC; Cátedra de Microbiología, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Páez PL; Facultad de Farmacia de Albacete, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Albacete, 02008, España.
  • Paraje MG; Cátedra de Microbiología, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
Nanomedicine (Lond) ; 17(22): 1663-1676, 2022 09.
Article em En | MEDLINE | ID: mdl-36515357
Biofilms are at least 100­1000-times more resistant to the effects of antimicrobial agents compared with planktonic cells, and nanoparticles have emerged to provide new approaches to improve the safety and efficacy of antimicrobial therapy. The aim of this work was to investigate the antifungal activity with two different functionalized gold nanoparticles. A significant reduction of Candida tropicalis biofilms with alterations in surface topography and architecture was observed, and the oxidative and nitrosative stress affected the biofilms. To the best of our knowledge, this is the first study that attempts to correlate the antibiofilm effects of gold nanoparticles on the redox imbalance against biofilms. These compounds could be an alternative to fungal biofilms infections treatments, applied specifically in biological and medical fields.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida tropicalis / Nanopartículas Metálicas Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida tropicalis / Nanopartículas Metálicas Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido