Anti-parkinsonian effect of the mGlu<sub>2</sub> positive allosteric modulator LY-487,379 as monotherapy and adjunct to a low L-DOPA dose in the MPTP-lesioned marmoset.

Frouni, Imane; Kwan, Cynthia; Belliveau, Sébastien; Hamadjida, Adjia; Bédard, Dominique; Nuara, Stephen G; Gourdon, Jim C; Huot, Philippe

Anti-parkinsonian effect of the mGlu₂ positive allosteric modulator LY-487,379 as monotherapy and adjunct to a low L-DOPA dose in the MPTP-lesioned marmoset.

Frouni, Imane; Kwan, Cynthia; Belliveau, Sébastien; Hamadjida, Adjia; Bédard, Dominique; Nuara, Stephen G; Gourdon, Jim C; Huot, Philippe.

Afiliação

Frouni I; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Kwan C; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Belliveau S; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Hamadjida A; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Bédard D; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Nuara SG; Comparative Medicine & Animal Resource Centre, McGill University, Montreal, QC, Canada.
Gourdon JC; Comparative Medicine & Animal Resource Centre, McGill University, Montreal, QC, Canada.
Huot P; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada; Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada; Movement Disorder

Eur J Pharmacol ; 939: 175429, 2023 Jan 15.

Article em En | MEDLINE | ID: mdl-36502960

Assuntos

Levodopa; Transtornos Parkinsonianos; Animais; Levodopa/farmacologia; Levodopa/uso terapêutico; Antiparkinsonianos/farmacologia; Antiparkinsonianos/uso terapêutico; Callithrix; Transtornos Parkinsonianos/tratamento farmacológico

Palavras-chave

Dyskinesia; MPTP; Marmoset; Parkinson's disease; Parkinsonism; Positive allosteric modulation; Positive allosteric modulator; Psychosis; mGlu(2)

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Levodopa / Transtornos Parkinsonianos Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google